Purification and Identification of Antioxidant Substances in Human-Placenta Extracts
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概要
- 論文の詳細を見る
We attempted to purify and identify the active antioxidants in human-placenta extracts (PLx). Purification was performed successively by 40% methanol precipitation, Sephadex G-50 gel chromatography, and high-performance liquid chromatography (HPLC). The supernatant of PLx after 40% methanol precipitation possessed 85% of the original antioxidant activity. Elution of the antioxidants from gel chromatography gave mainly three peaks with approximately 98% recovery of the antioxidant activity. The antioxidant activity was then fractionated by HPLC with a recovery of approximately 90% of the activity. Three components were obtained, and based on HPLC retention times, UV, NMR, and FAB-MASS, they were identified as uracil, tyrosine, and phenylalanine.
- 公益社団法人日本薬学会の論文
- 2000-04-01
著者
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渡辺 聡
星薬科大学衛生化学教室
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Takahashi Noriko
星薬科大学医薬品化学研究所 病態機能制御学研究室
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Takahashi N
Faculty Of Pharmaceutical Sciences Hoshi University
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WATANABE Satoshi
Department of Rehabilitation Medicine, St. Marianna University Hospital
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Watanabe Satoshi
星薬科大学 薬学部衛生化学
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渡辺 聡
星薬大・薬
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Watanabe Satoshi
Aono Atomcraft Project Erato Research Development Corporation
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Watanabe Satoshi
Faculty Of Pharmaceutical Sciences Hoshi University
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Watanabe Satoshi
Hoshi University
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Watanabe Satoshi
Department Of Agricultural Chemistry University Of Tokyo
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Watanabe Satoshi
Advanced Research Laboratory Hitachi Ltd.
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Takahashi Noriko
Faculty Of Pharmaceutical Sciences Hoshi University
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Takahashi Noriko
Department Of Biochemistry University Of Shizuoka School Of Pharmaceutical Sciences Core Research Fo
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Takahashi N
Laboratory Of Physiological Chemistry Institute Of Medicinal Chemistry Hoshi University
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渡辺 聡
星薬大
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FUKUI Tetsuya
Department of Health Chemistry, Hoshi University
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Fukui T
Hoshi Univ. Tokyo Jpn
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Fukui T
Byotai‐seiri Lab. Tokyo Jpn
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Fukui Tetsuya
Department Of Health Chemistry
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Fukui Tetsuya
Hoshi University
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TOGASHI Shin-ichi
Department of Health Chemistry, Faculty of Pharmaceutical Sciences, Hoshi University
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KUBO Yoshinori
Department of Health Chemistry, Faculty of Pharmaceutical Sciences, Hoshi University
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Shigihara Atsushi
Department of Health Chemistry, Faculty of Pharmaceutical Sciences, Hoshi University
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Higashiyama Kimio
Department of Health Chemistry, Faculty of Pharmaceutical Sciences, Hoshi University
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KUBO Yoshinori
Laboratory of Physiological Chemistry, Institute of Medicinal Chemistry, Hoshi University
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Shigihara Atsushi
Department Of Health Chemistry Faculty Of Pharmaceutical Sciences Hoshi University
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Watanabe S
Hoshi Univ. Tokyo Jpn
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Fukui T
Byotai-seiri Laboratory
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Kubo Yoshinori
Laboratory Of Physiological Chemistry Institute Of Medicinal Chemistry Hoshi University
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Kubo Yoshinori
Department Of Health Chemistry Hoshi University
-
Fukui T
Department Of Materials Science And Engineering Faculty Of Engineering Kyushu University
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Togashi Shin-ichi
Department Of Health Chemistry Faculty Of Pharmaceutical Sciences Hoshi University
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Higashiyama Kimio
Department Of Health Chemistry Faculty Of Pharmaceutical Sciences Hoshi University
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