Suppressive Effect of Curcumin on Trichloroethylene-induced Oxidative Stress
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概要
- 論文の詳細を見る
In vivo antioxidative effects of curcumin were investigated using a trichloroethylene (TCE)-induced oxidative stress model in mouse liver. Increases in the con-tents of peroxisome and thiobarbituric acid reactive substances (TBARS) and decreases in GSH content of mouse liver by the TCE administration were suppressed by the pre-adminis-tration of curcumin. TCE-induced changes in the activities of antioxidative enzyme, such as Cu/Zn-SOD, catalase, glutathione reductase, glutathione peroxidase (GPx) and D-glucose-6-phosphate dehydrogenase (G6PD), were also diminished by curcumin. These results indi-cate that curcumin significantly suppresses TCE-induced oxidative stress by scavenging var-ious free radicals, and its antioxidative activity seems to be derived from its suppressive ef-fects on the increase in peroxisome content and decrease in GPx and G 6PD activities.
- 財団法人 学会誌刊行センターの論文
- 2000-10-01
著者
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渡辺 聡
星薬科大学衛生化学教室
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Watanabe Satoshi
星薬科大学 薬学部衛生化学
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渡辺 聡
星薬大・薬
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Watanabe Satoshi
Aono Atomcraft Project Erato Research Development Corporation
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Watanabe Satoshi
Faculty Of Pharmaceutical Sciences Hoshi University
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Watanabe Satoshi
Hoshi University
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Watanabe Satoshi
Department Of Agricultural Chemistry University Of Tokyo
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Watanabe Satoshi
Advanced Research Laboratory Hitachi Ltd.
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渡辺 聡
星薬大
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Fukui Tetsuya
Department Of Health Chemistry
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Watanabe S
Hoshi Univ. Tokyo Jpn
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FUKUI Tetusya
Department of Health Chemistry, Faculty of Pharmaceutical Sciences, Hoshi University
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Fukui Tetusya
Department Of Health Chemistry Faculty Of Pharmaceutical Sciences Hoshi University
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