臭素酸カリウムの毒性学的研究(第3報)臭素酸カリウム投与時におけるビタミンEの効果

概要

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The antioxidative effects of vitamin E (VE) on the administration of potassium bromate (KBrO_3) were examined. Five-week-old SPF-SD male rats were fed the VE enriched diets containing 250 or 1000 ppm VE in commercial diet (CE-2,VE 70ppm) for 4 weeks. KBrO_3 was given in drinking water for 4 weeks at the concentration of 1000 μg/ml and the following results were obtained. 1. KBrO_3 administration inhibited the gain in body weight, while it increased the weight of kidney in rats. 2. The contents of urea nitrogen (UN) and creatinine in the serum increased remarkably and the kidney injury was observed in the groups with KBrO_3 administration. 3. The activities of alkaline phosphatase (EC 3.1.3.1,ALP) and γ-glutamyl transpeptidase (EC 2.3.2.2,γ-GTP) in the kidney cytosols decreased to be about 60-70% of those in control groups. 4. The thiobarbituric acid reactive substances (TBRAS) contents in the liver and kidney homogenates decreased in the groups with VE enriched diet administration.
社団法人日本薬学会の論文
1993-12-31