水銀とセレン同時投与時のラット組織における両元素の蓄積と排泄

概要

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The accumulation and clearance of mercury and selenium in the various tissues of rats injected with mercuric chloride and/or sodium selenite were studied. The concentrations of mercury and selenium in the blood of rats receiving both elements decreased with time and reached the blood levels of untreated rats about 56 days after dosing. Clearance rates of mercury and selenium in the liver and spleen were much lower when administered simultaneously than when administered alone. The same phenomenon was found on clearance rate of selenium in the kidney. However, the clearance rate of mercury in the kidney of rats injected with both mercury and selenium approximately agreed with that in the kidney of rats receiving mercury only between 14 and 112 days after administration. The molar ratio (Hg/Se) in the kidney of rats receiving both elements was much greater than 1 during the 112 days observation period. The results of this study indicated that the mercury and selenium accumulated in the various tissues of rats by the interaction of both elements were gradually eliminated.
社団法人日本薬学会の論文
1983-06-30