セレンによる水銀の減毒作用に関する研究(第3報)水銀およびセレン同時投与群における血漿中の水銀とセレンの反応機構

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The reaction mechanism of mercury with selenium in the plasma of rats simultaneously injected HgCl_2 and Na_2SeO_3 was investigated. Sera collected after independent or simultaneous injection of HgCl_2 (10 μmol/kg, i.p. or i.v.) and Na_2SeO_3 (10 μmol/kg, s.c.) were chromatographed on Sephadex G-200 column. Distribution of mercury and selenium in the serum protein fractions of each injection group was determined by atomic absorption analysis and neutron activation analysis. On the other hand, bovine serum albumin, reduced glutathione, Na_2SeO_3,and HgCl_2 were reacted as the model reaction of mercury with selenium in the plasma. The reaction product of mercury with selenium in this reaction was chromatographed on Sephadex G-200 column and compared with in vivo experimental results. These results suggested that the final reaction product of mercury with selenium in the plasma was a colloidal HgSe, formed by the following two reactions : (1) Mercury from the Hg-binding protein transfers to the Se-binding protein and forms an intermediate such as protein-S-Se-Hg^+. (2) The Hg-binding protein reacts with the Se-binding protein and forms an intermediate such as protein-S-Hg-Se-S-protein, or selenium from the Se-binding protein transfers to the Hg-binding protein and forms an intermediate such as protein-S-Hg-Se^-. Finally, these intermediates decompose to HgSe and then it converts to colloidal HgSe by association. The latter reaction was proved to occur in the plasma after simultaneous injection of HgCl_2 (i.v.) and Na_2SeO_3 (s.c.).
社団法人日本薬学会の論文
1977-08-31

セレンによる水銀の減毒作用に関する研究(第3報)水銀およびセレン同時投与群における血漿中の水銀とセレンの反応機構

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