マウスの急性アルコール性肝障害に対するフラビンアデニンジヌクレオチドの抑制機構の検討

概要

論文の詳細を見る
With respect to the acute alcoholic liver injury in the mice by the administration of 86 mmol/kg of ethanol, 9.5 μmol/kg, 95 μmol/kg or 190 μmol/kg of flavin adenine dinucleotide (FAD) was administered to mice at 3 times before the administration of ethanol. The changes in the parameters, such as body weight, liver weight, flavin content, thiobarbituric acid reactive substances content and mitochondrial ADP/O ratio in the liver etc., by the administration of ethanol were dose dependently suppressed by FAD. It is suggested that an increase of lipid peroxidation and a decrease of mitochondrial ATP synthesis in the liver of mice caused by ethanol relate to the acute alcoholic liver injury. FAD shows a suppressive effect on the acute alcoholic liver injury by the decrease of lipid peroxidation and the restoration of mitochondrial ATP synthesis in the liver.
日本ビタミン学会の論文
1994-06-25