Effects of Development on Acetoacetyl-CoA Synthetase Biosynthesis in Rat Liver

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概要

• 論文の詳細を見る

• In order to investigate the physiological role of acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, EC 6.2.1.16), a cytosolic acetoacetate-activating enzyme, the effects of animal development on the activity and content of the enzyme were examined in rat liver. In male rats, the enzyme specific activity increased 21-fold at 4 weeks of age from that at 2 weeks of age, and then gradually decreased, while in female rats, it increased similarly to that of male rats, but further increased, reaching a maximum about 3-fold higher than that of male rats, at 6 weeks of age. The developmental patterns of the enzyme content correlated with that of the enzyme specific activity. These results indicate that changes in this enzyme activity and content during the developmental process might influence the rate of ketone body utilization for the formation of physiologically important lipidic substances in rat liver.

• 社団法人日本薬学会の論文
• 1999-09-15

著者

• Takahashi Noriko

  星薬科大学医薬品化学研究所 病態機能制御学研究室

• Takahashi N

  Faculty Of Pharmaceutical Sciences Hoshi University

• Takahashi Noriko

  Faculty Of Pharmaceutical Sciences Hoshi University

• Takahashi Noriko

  Department Of Biochemistry University Of Shizuoka School Of Pharmaceutical Sciences Core Research Fo

• Takahashi N

  Laboratory Of Physiological Chemistry Institute Of Medicinal Chemistry Hoshi University

• Takahashi Noriko

  Laboratory Of Physiological Chemistry Institute Of Medicinal Chemistry Hoshi University

• NAKAMOTO Mayumi

  Department of Health Chemistry, Hoshi University

• IWAHORI Akiyo

  Department of Health Chemistry, Hoshi University

• SATO Hiroki

  Department of Health Chemistry, Hoshi University

• FUKUI Tetsuya

  Department of Health Chemistry, Hoshi University

• Iwahori A

  Hoshi Univ. Tokyo Jpn

• Iwahori Akiyo

  Department Of Health Chemistry Faculty Of Pharmaceutical Sciences Hoshi University

• Fukui T

  Byotai‐seiri Lab. Tokyo Jpn

• Fukui Tetsuya

  Department Of Health Chemistry

• Fukui Tetsuya

  Hoshi University

• Fukui T

  Byotai-seiri Laboratory

• Fukui T

  Department Of Materials Science And Engineering Faculty Of Engineering Kyushu University

• Nakamoto Mayumi

  Department Of Health Chemistry Hoshi University

• Sato Hiroki

  Department Of Bioengineering Tokyo Institute Of Technology

• Sato Hiroki

  Department Of Health Chemistry Hoshi University

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