Biological Activity of α-Thujaplicin, the Isomer of Hinokitiol(Biochemistry/Molecular Biology)
スポンサーリンク
概要
- 論文の詳細を見る
α-Thujaplicin, a minor component of Aomori Hiba (Thujopsis dolabrata SIEB. et ZUCC. van hondai MAKING), showed rather strong antifungal activity against seven kinds of plant-pathogenic fungi, their minimum inhibitory concentrations (MICs) being in the range of 12.0-50.0 μg/ml. α-Thujaplicin and hinokitiol (the major component of Aomori Hiba) also showed clear antibacterial activity against Legionella pneumophila SG 1 and L. pneumophila SG 3, and their MICs are in the range of 6.25-50 μg/ml. This compound showed strong insecticidal activity against Reticulitermes speratus [50%-lethal concentration (LC_<50>): 0.02 g/m^2], and it also had clear acaricidal activity against Dermatophagoides farinae (LC_<50>: 0.66 g/m^2). At 24 h after treatment, α-thujaplicin at 0.63 μg/ml inhibited the cell growth of murine P388 lymphocytic leukemia by 78%, and its cytotoxic activity at a concentration higher than 0.63 μg/ml was as high as that of vincristine, used as a positive control. On the other hand, the cytotoxic effect of α-thujaplicin at 0.63/lg/ml was weaker than that of vinblastine. In this respect, the strong cytotoxic effect of α-thujaplicin on murine P388 lymphocytic leukemia cell line should be emphasized, considering that it has recently been found to be low in toxicity to mice.
- 公益社団法人日本薬学会の論文
- 2004-06-01
著者
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Matsumura E
Osaka University Of Pharmaceutical Sciences
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Matsumura Eiko
Osaka University Of Pharmaceutical Sciences
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Inamori Yoshihiko
Department Of Microbiology Osaka University Of Pharmaceutical Sciences
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SHIBANO Makio
Osaka University of Pharmaceutical Sciences
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Shibano M
Laboratory Of Pharmacognostical Sciences Osaka University Of Pharmaceutical Sciences
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Shibata M
Fumakilla Ltd.
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Morita Y
Osaka Organic Chemical Industry Ltd.
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TSUJIBO Hiroshi
Osaka University of Pharmaceutical Sciences
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INAMORI Yoshihiko
Osaka University of Pharmaceutical Sciences
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Fukui T
Hoshi Univ. Tokyo Jpn
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Fukui T
Byotai‐seiri Lab. Tokyo Jpn
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Okabe Toshihiro
Department Of Surgery Tokyo Women's Medical University Daini Hospital
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Morita Yasuhiro
Osaka Organic Chemical Industry Ltd
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OKABE TOSHIHIRO
Aomori Industrial Research Center
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OHE TATSUHIKO
Osaka Manicipal Research Institute
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ISHIDA NAKAO
The Sendai Institute of Microbiology
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FUKUI Toru
Byotai-Seiri Laboratory
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TSUJIBO Hiroshi
Department of Microbiology, Osaka University of Pharmaceutical Sciences
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SHIBATA Mitsunobu
Fumakilla Ltd.
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SUGIURA Masaaki
Fumakilla Ltd.
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Okabe T
Aomori Industrial Research Center
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Shibano M
Osaka University Of Pharmaceutical Sciences
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Ishida N
The Sendai Institute Of Microbiology
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Fukui T
Byotai-seiri Laboratory
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Okabe Toshihiro
Department Of Endocrine Surgery Tokyo Women's Medical University
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Miki Y
Kinki Univ. Higashi‐osaka Jpn
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Fukui T
Department Of Materials Science And Engineering Faculty Of Engineering Kyushu University
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Tsujibo H
Department Of Microbiology Osaka University Of Pharmaceutical Sciences
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Inamori Yoshihiko
Osaka College Of Pharmacy
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FUKUI Toru
Byotai Seiri Laboratory
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