Two New Pyrrolidine Alkaloids, Broussonetines Y and Z from Broussonetia kazinoki SIEB. and Activity of Glycosidases Inhibition by N-Alkylation of Broussonetines
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概要
- 論文の詳細を見る
Two new pyrrolidine alkaloids, broussonetines Y and Z (1,2) were isolated from the branches of Broussonetia kazinoki SIEB. (Moraceae) in low yield. They were formulated as 2β-hydroxymethyl-3α,4β-dihydroxy-5α-(9,10,13-trihydroxytridecyl) pyrrolidine (1), 2β-hydroxymethy1-3α,4β-dihydroxy-5α-(1ξ,13-dihydroxy-5:10;10:6-diepoxytridecyl) pyrrolidine (2), respectively, by spectroscopic and chemical methods. N-Alkyl derivatives of brousssonetinine A showed stronger inhibition for β-galactosidase than the original, while N-alkyl derivatives of broussonetines D and F showed weaker inhibition for glycosidases than the originals.
- 日本生薬学会の論文
- 2003-04-20
著者
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SHIBANO Makio
Osaka University of Pharmaceutical Sciences
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KUSANO Genjiro
Osaka University of Pharmaceutical Sciences
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Shibano M
Laboratory Of Pharmacognostical Sciences Osaka University Of Pharmaceutical Sciences
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Shibata M
Fumakilla Ltd.
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TSUKAMOTO Daisuke
Osaka University of Pharmaceutical Sciences
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Shibano M
Osaka University Of Pharmaceutical Sciences
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Kusano G
Osaka University Of Pharmaceutical Sciences
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Kusano Genjiro
Osaka University Of Phamaceutical Sciences
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