Studies on the Constituents of Broussonetia Species. VII. Four New Pyrrolidine Alkaloids, Broussonetines M, O, P, and Q, as Inhibitors of Glycosidase, from Broussonetia kazinoki SIEB.
スポンサーリンク
概要
- 論文の詳細を見る
Four new pyrrolidine alkaloids, broussonetines M, O, P, and Q, were isolated from the branches of Broussonetia kazinoki SIEB. (Moraceae). Broussonetines M, O, P, and Q were formulated as (2R, 3R, 4R, 5R)-2-hydroxymethyl-3,4-dihydroxy-5-[(10S)-10,13-dihydroxy-tridecyl]pyrrolidine (1), (2R, 3R, 4R, 5R)-2-hydroxymethyl-3,4-dihydroxy-5-[(E)9-oxo-13-hydroxy-3-tridecenyl]pyrrolidine (2), (2R, 3R, 4R, 5R)-2-hydroxymethyl-3,4-dihydroxy-5-[(E)10-oxo-13-hydroxy-3-tridecenyl]pyrrolidine (3), and (2R, 3R, 4R, 5R)-2-hydroxymethyl-3-hydroxy-4-(β-D-glucopyranosyloxy)-5-[10-oxo-13-(β-D-glucopyranosyloxy)tridecyl]pyrrolidine (4) respectively, by spectroscopic and chemical methods. 1-4 inhibited β-glucosidase, β-galactosidase and β-mannosidase.
- 公益社団法人日本薬学会の論文
- 2000-09-01
著者
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Fujimoto Rie
Osaka University Of Pharmaceutical Sciences
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SHIBANO Makio
Osaka University of Pharmaceutical Sciences
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KUSANO Genjiro
Osaka University of Pharmaceutical Sciences
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Shibano M
Laboratory Of Pharmacognostical Sciences Osaka University Of Pharmaceutical Sciences
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Shibata M
Fumakilla Ltd.
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TSUKAMOTO Daisuke
Osaka University of Pharmaceutical Sciences
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MASUI Yasue
Osaka University of Pharmaceutical Sciences
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SUGIMOTO Hisako
Osaka University of Pharmaceutical Sciences
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Kusano G
Osaka University Of Pharmaceutical Sciences
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Masui Yasue
Osaka University Of Pharmaceutical Science
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Kusano Genjiro
Osaka University Of Phamaceutical Sciences
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Masui Yasushi
Osaka University Of Pharmaceutical Science
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