A New Pyrrolizidine Alkaloid, Broussonetine N, as an Inhibitor of Glycosidase, from Broussonetia kazinoki SIBE. and Absolute Stereostructures of Broussonetines A and B
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概要
- 論文の詳細を見る
A new pyrrolizidine alkaloid, broussonetine N, was isolated from the branches of Broussonetia kazinoki SIEB. (Moraceae).Broussonetine N was formulated as (1R, 2R, 3R, 5S, 8R)-1,2-dihydroxy-3-hydroxymethyl-5[(1R)-1,10-dihydroxy-6-oxo-decyl]pyrrolizidine (1) by spectoroscopic and chemical methods. 1 inhibited β-glucosidase, β-galactosidase, and β-mannosidase. Absolute stereostructures of broussonetines A (2) and B (3) as well as that of 1 were also determined by a new version of Mosher's method.
- 公益社団法人日本薬学会の論文
- 1999-06-15
著者
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SHIBANO Makio
Osaka University of Pharmaceutical Sciences
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KUSANO Genjiro
Osaka University of Pharmaceutical Sciences
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Shibano M
Laboratory Of Pharmacognostical Sciences Osaka University Of Pharmaceutical Sciences
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Shibata M
Fumakilla Ltd.
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TSUKAMOTO Daisuke
Osaka University of Pharmaceutical Sciences
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Kusano G
Osaka University Of Pharmaceutical Sciences
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Kusano Genjiro
Osaka University Of Phamaceutical Sciences
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