Vasoactive Effects of Cimicifugic Acids C and D, and Fukinolic Acid in Cimicifuga Rhizome
スポンサーリンク
概要
- 論文の詳細を見る
Vasoactive effects of cimicifugic acids A-E, fukinolic acid and fukiic acid isolated from Cimicifuga plants were investigated using rat aortic strips. Cimicifugic acid D and fukinolic acid at 3×10^<-4>M caused a sustained, slowly developing relaxation of aortic strips precontracted with norepinephrine (NE) in preparations with or without endothelium. Cimicifugic acid C inversely caused a weak contraction. Cimicifugic acids A, B and E and fukiic acid showed no vasoactivity at 3×10^<-4> M. Cimicifugic acids A-E and fukinolic acid are esters between cinnamic acids and the hydroxyl group of benzyltartaric acids. For the manifestation of vasoactivity in the rat aorta, it is concluded that in the cinnamic acid moiethy, a caffeoyl group might be necessary for the relaxaion activity, and the p-coumaroyl group causes contraction.Concentration response curves for the Ca^<2+>-induced contracture of depolarized aortic strips with isotonic high K^+ were not affected by cimicifugic acid D or fukinolic acid. The Ca^<2+>-induced contraction of aortic strips, preincubated with 10^<-6> M NE in the prsence of 10^<-6> M nicardipine and 0.01 mM EGTA in Ca^<2+>-free solution, were inhibited by cimicifugic acid D and fukinolic acid. These results indicated that the inhibition by cimicifugic acid D and fukinolic acid of the NE-induced contraction of rat aorta are attributable to the suppression of Ca^<2+> influx from the extracellular space enhanced by NE.
- 公益社団法人日本薬学会の論文
- 1998-11-15
著者
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TAKAHIRA Masayuki
Osaka University of Pharmaceutical Sciences
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KUSANO Genjiro
Osaka University of Pharmaceutical Sciences
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NAGAI Masahiro
Faculty of Pharmaceutical Sciences, Hoshi University
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Nagai M
Faculty Of Pharmaceutical Sciences Hoshi University
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Nagai Masahiro
Department Of Medicinal Plant Sciences Hoshi University
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Nagai M
Hoshi Univ. Tokyo Jpn
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Nagai Masahiro
Faculty Of Pharmaceutical Sciences Hoshi University
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Sakurai N
Hoshi Univ. Tokyo Jpn
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Sakurai Nobuko
Faculty Of Pharmaceutical Sciences Hoshi University
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Noguchi M
Faculty Of Pharmaceutical Sciences Hoshi University
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NOGUCHI Mariko
Faculty of Pharmaceutical Sciences, Hoshi University
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KOEDA Mamoru
Faculty of Pharmaceutical Sciences, Hoshi University
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NAKAYAMA Shigeki
Faculty of Pharmaceutical Sciences, Hoshi University
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Kusano G
Osaka University Of Pharmaceutical Sciences
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Koeda Mamoru
Faculty Of Pharmaceutical Sciences Hoshi University
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Kusano Genjiro
Osaka University Of Phamaceutical Sciences
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Nagai Masahiro
Faculty Of Human Environments Studies The University Of Human Environments
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Nakayama S
Faculty Of Pharmaceutical Sciences Hoshi University
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Noguchi Mariko
Faculty Of Pharmaceutical Sciences Hoshi University
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NAGAI Masahiro
Faculty of Human Environment, University of Human Environments
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