Inhibition of LysoPAF Acetyltransferase Activity by Components of Licorice Root

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概要

• 論文の詳細を見る

• Licorice root traditionally used as an anti-inflammatory drug exhibited an inhibitory effect on lysoPAF (platelet-activating factor) acetyltransferase in vitro : the ether soluble fraction of the crude drug produced a 27.3% inhibition at a concentration 10 μg/ml. From this fraction, licorcidin (1), 1-methoxyphaseollin (2), 6,8-diprenylgenistein (3) and 1-methoxyphaseollidin (4) were isolated as active components, whose IC_<50> values were 7.7,57 19 and 48 μM, respectively. Licoricidin (1) seems to be one of the most potent compounds of plant origin isolated so far.

• 公益社団法人日本薬学会の論文
• 1999-10-15

著者

• Nagumo S

  Hoshi Univ. Tokyo Jpn

• NAGUMO Seiji

  Faculty of Pharmaceutical Sciences, Hoshi University

• NAGAI Masahiro

  Faculty of Pharmaceutical Sciences, Hoshi University

• Nagumo Seiji

  Faculty Of Pharmaceutical Sciences Hoshi University

• Nagai M

  Faculty Of Pharmaceutical Sciences Hoshi University

• Nagai Masahiro

  Department Of Medicinal Plant Sciences Hoshi University

• Nagai Masahiro

  Faculty Of Pharmaceutical Sciences Hoshi University

• Nagumo S

  (present Address)hokkaido Institute Of Pharmaceutical Science

• YANOSHITA Ryohei

  Institute of Medicinal Chemistry, Hoshi University

• Yanoshita Ryohei

  Institute Of Medicinal Chemistry Hoshi University

• Nagai Msahiro

  Department Of Medicinal Plant Sciences Hoshi University

• SAMEJIMA Yuji

  Institute of Medicinal Chemistry, Hoshi University

• FUKUJU Akira

  Faculty of Pharmaceutical Sciences, Hoshi University

• TAKAYAMA Mitsue

  Faculty of Pharmaceutical Sciences, Hoshi University

• Samejima Y

  Hoshi Univ. Tokyo

• Samejima Yuji

  Institute Of Medicinal Chemistry Hoshi University

• Yanoshita R

  Hoshi Univ. Tokyo

• Fukuju Akira

  Faculty Of Pharmaceutical Sciences Hoshi University

• Nagumo S

  Hokkaido Coll. Pharmacy Otaru Jpn

• Takayama M

  Faculty Of Pharmaceutical Sciences Hoshi University

• Nagai Masahiro

  Faculty Of Human Environments Studies The University Of Human Environments

• Takayama Mitsue

  Faculty Of Pharmaceutical Sciences Hoshi University

• NAGAI Masahiro

  Faculty of Human Environment, University of Human Environments

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