Inhibition of LysoPAF Acetyltransferase by the Ingredients from Lithospermum Root

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概要

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• Lithospermum Root traditionally used as an anti-inflammatory drug exhibited an inhibitory effect on lysoPAF acetyltransferase in vitro : the ether extract of the crude drug inhibited 53% at a concentration of 10μg/ml. From the extract, isobutyrylshikonin, β, β-dimethylacrylshikonin shikonin, acetylshikonin, β-hydroxyisovalerylshikonin, and shikonofuran E were isolated as active components, whose IC_<50> values were 9.7, 11, 13, 19, 26, and 8.4 μM, respectively.

• 日本生薬学会の論文
• 2001-10-20

著者

• Nagumo Seiji

  Faculty Of Pharmaceutical Sciences Hoshi University

• Kusunoki Natsuko

  Faculty Of Pharmaceutical Sciences Hoshi University

• Samejima Yuji

  Institute Of Medicinal Chemistry Hoshi University

• Nagai Masahiro

  Faculty Of Human Environments Studies The University Of Human Environments

• NAGAI Msahiro

  Faculty of Pharmaceutical Sciences, Hoshi University

• YONOSHITA Ryohei

  Institute of Medicinal Chemistry, Hoshi University

• Yonoshita Ryohei

  Institute Of Medicinal Chemistry Hoshi University

• Nagai Msahiro

  Faculty Of Pharmaceutical Sciences Hoshi University

• NAGAI Masahiro

  Faculty of Human Environment, University of Human Environments

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