Comparison of serum ferritin and oxidative stress biomarkers between Japanese workers with and without metabolic syndrome
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概要
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ObjectiveMetabolic syndrome (MS) is closely associated to life-style and is characterized by central obesity causing severe diseases such as diabetes mellitus (DM) or atherosclerosis. This study investigates the role of oxidative stress and inflammation in MS.SubjectsTotal of 685 workers stratified by gender (293 men and 392 women) with a mean age of 41.2 ± 10.4 in different offices in a city in Japan.MethodsFasting blood and urine tests for MS, oxidative and/or inflammatory biomarker analysis and blood pressure (BP) measurement were performed. MS was defined on the basis of the Japanese criterion.ResultsSerum ferritin and urinary hydrogen peroxide (H2O2) levels were significantly higher in subjects with MS than those without. Ferritin was positively correlated with 8-hydroxy-2′-deoxyguanosine (8-OHdG) in all subjects and it was negatively correlated with 8-isoprostane and H2O2 in men. In addition, there was a significant positive correlation between ferritin and homeostasis model assessment (HOMA-R) in men. By using multiple regression analysis, ferritin was closely correlated with HOMA-R, γ-GT, 8-OHdG, smoking value and amount of alcohol ingestion in men, and it was correlated with 8-OHdG, γ-GT, HOMA-R in women under 50 years old.ConclusionsFerritin is a useful marker of MS including insulin resistance, reflecting the importance of oxidative stress as a cause of MS, especially in men.
- 公益社団法人 日本獣医学会の論文
著者
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Takahashi Noriko
Department Of Biochemistry University Of Shizuoka School Of Pharmaceutical Sciences Core Research Fo
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Ogino Keiki
Department Of Environmental And Preventive Medicine Graduate School Of Medical Science Kanazawa Univ
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Wang Da-hong
Department Of Public Health Okayama University Graduate School Of Medicine And Dentistry
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Taketa Kazuhisa
Department Of Hepatogastroenterology Okayama University School Medicine
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Hori Yasutomo
Department Of Internal Medicine School Of Veterinary Medicine & Animal Science Kitasato Universi
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Sakano Noriko
Department Of Hygiene Faculty Of Medicine Kagawa University
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Takahashi Hidekazu
Department Of Advanced Biomaterials Division Of Oral Health Sciences Graduate School Tokyo Medical A
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CHIKAZAWA Seishiro
Department of Small Animal Internal Medicine, School of Veterinary Medicine, Kitasato University, 23–35–1 Higashi, Towada, Aomori 034–8628, Japan
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Iwanaga Suketaka
Department of Small Animal Internal Medicine, School of Veterinary Medicine, Kitasato University, 23–35–1 Higashi, Towada, Aomori 034–8628, Japan
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Kubo Masayuki
Laboratory of Biochemistry, School of Veterinary Medicine, Kitasato University, 23–35–1 Higashi, Towada, Aomori 034–8628, Japan
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Miyatake Nobuyuki
Laboratory of Biochemistry, School of Veterinary Medicine, Kitasato University, 23–35–1 Higashi, Towada, Aomori 034–8628, Japan
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HOSHI Fumio
Department of Small Animal Internal Medicine, School of Veterinary Medicine, Kitasato University, 23–35–1 Higashi, Towada, Aomori 034–8628, Japan
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NAKAZAWA Takafumi
Department of Small Animal Internal Medicine, School of Veterinary Medicine, Kitasato University, 23–35–1 Higashi, Towada, Aomori 034–8628, Japan
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