Unmetabolized VOCs in Urine as Biomarkers of Low Level Exposure in Indoor Environments

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概要

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• Unmetabolized VOCs in Urine as Biomarkers of Low Level Exposure in Indoor Environments: Bing-Ling WANG, et al. Department of Public Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences-This study aimed to test the possible use of unmetabolized volatile organic compounds (VOCs) in urine as biomarkers of low-level indoor environmental exposure. Twenty-four subjects in 13 dwellings in a prefecture of Japan participated in this study. Air samples of the breathing zone were collected in the living room and bedroom, along with spot urine samples (before bedtime and first morning voids). Toluene, ethylbenzene, xylene isomers, styrene and p-dichlorobenzene in the air and urine samples were measured by gas chromatography/mass spectrometry. For the 21 subjects without solvent exposure at work, there were significant correlations between the timeweighted average air concentrations in the bedroom and morning urinary concentrations for toluene, o-xylene, total xylene and p-dichlorobenzene (correlation coefficients of 0.54, 0.61, 0.56 and O.84, respectively). Multiple linear regression analysis showed only air VOCs in the bedroom influenced the morning urinary VOC concentrations. We concluded that unmetabolized VOCs in the urine can provide a reliable biological indicator for air VOC exposures in non-occupational environments.

• 社団法人日本産業衛生学会の論文

著者

• OGINO Keiki

  Department of Public Health, Okayama University Graduate School of Medicine, Dentistry & Pharmaceuti

• Wang Da‐hong

  Okayama Univ. Graduate School Of Medicine Dentistry And Pharmaceutical Sci. Okayama Jpn

• WANG Da-Hong

  Department of Public Health, Okayama University Medical School, 2-5-1 Shikata-cho, Okayama 700, Japa

• WANG Bing-Ling

  Department of Public Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceu

• TAKIGAWA Tomoko

  Department of Public Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceu

• TAKEUCHI Akito

  Department of Public Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceu

• YAMASAKI Yukie

  Department of Public Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceu

• KATAOKA Hiroyuki

  School of Pharmacy, Shujitsu University

• Taniguchi Toshiyo

  Dep. Of Welfare System And Health Sci. Okayama Prefectural Univ.

• Taniguchi Toshiyo

  Department Of Welfare System And Health Science Okayama Prefectural University

• Wang Da-hong

  岡山大学 公衆衛

• Wang Da-hong

  Department Of Public Health Okayama University Medical School

• Wang Da-hong

  岡山大学 医学部放射線医学

• Ogino Keiki

  中国四国安全衛生サービスセンター

• Ogino Keiki

  Department Of Public Health Okayama University Graduate School Of Medicine Dentistry And Pharmaceuti

• Ogino K

  Department Of Public Health Okayama University Graduate School Of Medicine Dentistry & Pharmaceu

• Ogino K

  Medical School Kanazawa University

• Ogino Keiki

  Dep. Of Public Health Okayama Univ. Graduate School Of Medicine Dentistry And Pharmaceutical Science

• Wang Da-hong

  Department Of Public Health Okayama University Graduate School Of Medicine Dentistry And Pharmaceuti

• Wang Da-hong

  岡山大学 大学院医歯薬学総合研究科公衆衛生学分野

• Yamasaki Yukie

  Department Of Public Health Okayama University Graduate School Of Medicine Dentistry And Pharmaceuti

• Yamasaki Yukie

  岡山大学 医歯薬学総合研究科公衆衛生学

• Takigawa Tomoko

  Department Of Public Health Okayama University Graduate School Of Medicine Dentistry And Pharmaceuti

• Takigawa T

  Okayama Univ. Graduate School Of Medicine And Dentistry Okayama Jpn

• Takigawa Tomoko

  岡山大学 医歯総研究 公衛

• Wang Bing‐ling

  Department Of Public Health Okayama University Graduate School Of Medicine Dentistry And Pharmaceuti

• Wang D‐h

  Okayama Univ. Medical School Okayama Jpn

• Wang Bing-ling

  Department Of Public Health Okayama University Graduate School Of Medicine Dentistry And Pharmaceuti

• Ogino Keiki

  Department Of Public Health Okayama University Graduate School Of Medicine Dentistry & Pharmaceu

• Ogino Keiki

  Department Of Environmental And Preventive Medicine Graduate School Of Medical Science Kanazawa Univ

• Takeuchi Akito

  Osaka Occupational Health Service Center Japan Industrial Safety And Health Association

• Takeuchi Akito

  Chugoku-shikoku Safety And Health Center Japan Industrial Safety And Health Association

• Wang Da-hong

  Department Of Public Health Okayama University Graduate School Of Medicine And Dentistry

• Takigawa Tomoko

  Department Of Public Health Okayama University Graduate School Of Medical Dentistry And Pharmaceutic

• Kataoka Hiroyuki

  Department Of Health Science Kitasato University School Of Allied Health Sciences

• Takigawa Tomoko

  Department Of Welfare System And Health Science Okayama Prefectural University

• Kataoka Hiroyuki

  School Of Pharmacy Shujitsu University

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