THE EFFECTS OF OXYGEN TOXICITY ON THE PREGNANT RAT USING AN APPARATUS DESIGNED TO MEASURE OXYGEN CONSUMPTION METHOD
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概要
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To evaluate the effects of oxygen toxicity in the pregnant rat at high and low concentrations of oxygen, an oxygen-consumption apparatus was devised to measure the consumption of oxygen continuously over long periods. Oxygen consumption, partial oxygen pressure on the skin (tcPo_2), and lipid peroxide levels in the serum were measured. There was a close correlation between oxygen consumption and body weight of rats that weighed between 150 g and 450 g. Oxygen consumption during the later stages of pregnacy increased by 1.8 ml/day, an increase of 8%. Oxygen consumption by rats during parturition increased markedly for up to 1 h and then reached and remained at a plateau value until the end of delivery. Exposure of pregnant rats to low concentrations of oxygen resulted in a marked depression in oxygen consumption and tcPo_2 during the exposure time. A significant increase in the lipid peroxide level in serum was observed in the mother rat after birth and in the newborn offspring of pregnant rats exposed to 16% oxygen for 3 h.3h.Correspondence : Dr. Yoshihiro YOSHIMURA at the above address.
- 日本トキシコロジー学会の論文
- 1988-08-31
著者
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TANAKA Hiroshi
Department of Pediatrics, Hirosaki University School of Medicine
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YOSHIMURA Yoshihiro
Department of Analytical Chemistry, Hoshi University
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TSUTSUMI Tomoko
Daiyu-Kai Institute of Medical Science
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UCHIYAMA Katsumi
Department of Applied Chemistry, Graduate School of Engineering, Tokyo Metropolitan University
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TANAKA Tadao
Department of Obstetrics and Gynecology, The Jikei University School of Medicine
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Yoshimura Y
Keio Univ. Tokyo Jpn
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Yoshimura Yoshihiro
Department Of Analytical Chemistry Faculty Of Pharmaceutical Sciences Hoshi University
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Uchiyama Katsumi
Department Of Analytical Chemistry Faculty Of Pharmaceutical Sciences Hoshi University
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Tanaka Tadao
Department Of Environmental Safety Research Japan Atomic Energy Research Institute
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Ohtani Yoshiki
National Okura Hospital
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Tanaka Hiroshi
Department Of Cardiology Jichi Medical School
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OHSAWA Keiko
Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Hoshi University
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IMAEDA Kazuo
Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Hoshi University
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Tanaka Tadao
Drug Development Research Laboratories Pharma Research And Development Division Hoechst Japan Limite
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Imaeda Kazuo
Department Of Analytical Chemistry Faculty Of Pharmaceutical Sciences Hoshi University
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Ohsawa Keiko
Department Of Analytical Chemistry Faculty Of Pharmaceutical Sciences Hoshi University
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Ohsawa Keiko
Department Of Agricultural Chemistry Faculty Of Agriculture Shizuoka University
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Tamura Kohei
National Okura Hospital
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ARAKI Katsue
Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Hoshi University
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TSUTSUMI Toshio
Department of Clinical Research, National Okura Hospital
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OHTANI Yoshiki
Department of Clinical Research, National Okura Hospital
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TAMURA Kohei
Department of Clinical Research, National Okura Hospital
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Araki Katsue
Department Of Analytical Chemistry Faculty Of Pharmaceutical Sciences Hoshi University
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Tsutsumi Toshio
Department Of Clinical Research National Okura Hospital
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Tanaka Hiroshi
Department Of Analytical Chemistry Faculty Of Pharmaceutical Sciences Hoshi University
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