Th1/Th2-Balancing Immunomodulating Activity of Gel-Forming(1→3)-β-Glucans from Fungi
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概要
- 論文の詳細を見る
The immunomodulating effects of various gel-forming(1→3)-β-glucans, grifolan(GRN), SSG, sonifilan(SPG)and alkaline-treated SPG(SPG-OH), on balancing helper T cell activity were examined in a murine model. Plasma from mice that were injected with GRN or SPG-OH and trinitrophenyl ovalbumin(TNP-OVA)contained TNP-specific antibodies of both IgG1 and IgG2a isotypes. Administration of SSG and TNP-OVA significantly augmented the synthesis of IgG2a antibodies, while the synthesis of IgG1 was reduced. However, SPG did not enhance the antibody response. In the culture supernatants of splenocytes obtained from GRN- or SPG- OH-administered mice, high levels of IgG1 and low levels of IgG2a and IFN γ were detected. In contrast, high levels of IgG2a and IFN γ and low levels of IgG1 were detected in the case of administration of SSG. Furthermore, it was shown by intracellular cytokine staining that the proportion of IFn γ^+CD4^+ double-positive cells among the CD4^+ cells from mice administered SSG was most strongly increased by addition of PMA and A23187. On the other hand, the expression of IL-12 p40 mRNA was more markedly elevated in splenocytes after combined administration of TNP-OVA plus SSG than after administration of TNP-OVA alone. The highest IFN γ production was observed when adherent cells of mice administered TNP-OVA and SSG were cultured with TNP-primed lymphocytes. This effect of administration of SSG on IFN-γ production was completely inhibited by addition of anti-IL-12 mAb. In conclusion, our study showed that β-glucans have various effects on the Th1 or Th2-dependent antibody subclasses, in particular, SSG induces the development of Th1 cells via the IL-12 pathway.
- 社団法人日本薬学会の論文
- 2001-07-01
著者
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Suzuki Y
School Of Pharmaceutical Sciences University Of Shizuoka
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OHNO Naohito
Laboratory far Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pha
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Ohno Naohito
東京薬科大学 免疫学
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Ohno Naohito
東京薬科大学 薬 微生物
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Ohno Naohito
Lab. For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo Univ. Of Pharmacy And Lif
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Ohno N
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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Adachi Yoshiyuki
東京薬科大学 免疫学
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Adachi Y
Tokyo Univ. Pharmacy And Life Sci. Tokyo Jpn
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Adachi Yoshiyuki
Laboratory Far Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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YADOMAE Toshiro
Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pha
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Suzuki Y
Meijo Univ. Nagoya Jpn
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SUZUKI Yoko
Laboratory of Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Phar
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Shingo Yuko
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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Adachi Yoshiyuki
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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Suzuki Y
Department Of Pharmacobiology And Therapeutics Faculty Of Pharmacy Meijo University
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Ohno Naohito
Laboratory Of Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharma
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Ohno Naohito
Laboratory For Immunopharmacology Of Microbial Products Tokyo University Of Pharmacy And Life Scienc
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Suzuki Y
Core Research For Evolutional Science And Technology (crest Jst) University Of Shizuoka School Of Ph
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Suzuki Y
Faculty Of Pharmacy Meijo University
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Yadomae T
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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Ohno Naohito
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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