Wide Range of Molecular Weight Distribution of Mitogenic Substance(s) in the Hot Water Extract of a Chinese Herbal Medicine, Bupleurum chinense
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概要
- 論文の詳細を見る
In this study, we examined the contribution of lignin-like materials in lower molecular weight (MW) fractions from the hot water extract of Bupleuri Radix (Bupleurum chinense) (HWE-BR) for their immunopharmacological activities. Mitogenic activity was detected in all the fractions of MW ranges : lower than 1.0 kDa, 1.0-3.5 kDa, 3.5-10 kDa, and 10-50 kDa. After NaClO_2 treatment of these subfractions, UV spectra, ESR spectra, mitogenic activities on murine B-cells, and the activity of inducing nitric oxide in RAW 264.7 cells were significantly reduced, suggesting that lignin-like polyphenolic substance(s) of various MW might take part in these activityes. The intensity of ESR spectra and mitogenic activities were stronger in higher MW subfractions, thus the content of stable radical species and/or the degrees of polymerization would be important for their immunopharmacological activities.
- 公益社団法人日本薬学会の論文
- 1997-07-15
著者
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NOMOTO Kikuo
Department of Immunology Kyushu University
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OHNO Naohito
Laboratory far Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pha
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Ohno Naohito
東京薬科大学 免疫学
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Ohno Naohito
東京薬科大学 薬 微生物
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Ohno N
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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YADOMAE Toshiro
Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pha
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Ohno Naohito
Laboratory Of Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharma
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Ohno Naohito
Laboratory For Immunopharmacology Of Microbial Products Tokyo University Of Pharmacy And Life Scienc
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IZUMI Shigeru
Laboratory of Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Phar
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KAWAKITA Takuya
Kampo Research Laboratories, Kanebo Co., Ltd.,
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Ohno N
Laboratory Of Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharma
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Izumi S
Laboratory Of Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharma
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Izumi Shigeru
Laboratory Of Immunopharmacology Of Microbial Products Tokyo University Of Pharmacy And Life Science
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Nomoto K
Department Of Immunology Medical Institute For Bioregulation Kyushu University
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Kawakita T
Kampo Research Laboratories Kanebo Co. Ltd.
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Kawakita Takuya
Kampo (traditional Chinese Medicine) Research Laboratory Kanebo Co. Ltd.
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Yadomae T
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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