Effects of Human Recombinant Interferon-gamma on Immunological Parameters in Brain Tumor Patients : Report of Two Cases
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概要
- 論文の詳細を見る
Two patients with brain tumors were treated with human recombinant interferon-gamma (ReIFN-gamma) in a clinical phase II study, and its effects on their white blood cell counts, T cell subsets, natural killer (NK) cell activity, and tuberculin skin reactions were investigated. Leukopenia developed shortly after the start of therapy and persisted until its discontinuation, after which the white blood cell counts recovered. T cell subsets were dramatically altered, with an increase in OKT4^+ cells and a decrease in OKT8^+ cells, within 4 hours after the administration of ReIFN-gamma. NK cell activity was suppressed at 4 hours after administration but was slightly enhanced at 12 hours after administration. The tuberculin skin reaction was also enhanced during the therapy. ReIFN-gamma may be effective in augmenting host defenses against brain tumor.
- 日本脳神経外科学会の論文
- 1989-03-15
著者
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NOMOTO Kikuo
Department of Immunology Kyushu University
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Fukui Masashi
Department Of Neurosurgery Graduate School Of Medical Science Kyushu University
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Takeshita Iwao
Department Of Neurosurgery Faculty Of Medicine Medical Institute Of Bioregulation Kyushu University
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Takeshita Iwao
Department Of Neurosurgery Faculty Of Medicine Kyushu University
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KAMIKASEDA Kazufumi
Department of Neurosurgery, Kaizuka Hospital
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Fukui Masashi
Department Of Neurosurgery Faculty Of Medicine Medical Institute Of Bioregulation Kyushu University
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Fukui Masashi
Department Of Neurosurgery Faculty Of Medicine Kyushu University
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Kamikaseda Kazufumi
Department Of Neurosurgery Hamanomachi General Hospital
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NOMOTO Kikuo
Department of Immunology, Medical Institute of Bioregulation, Kyushu University
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