An Application of Heterotransplantation of a Human Glioma Cell Line to Hereditary Asplenic-athymic (Lasat) Mice
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概要
- 論文の詳細を見る
Hereditary asplenic-athymic (lasat) mice were used in a study of heterotransplantation of an established human glioma cell line designated KNS-42 derived from a glioblastoma located in the right posterior frontal and parietal lobes of a 16-year-old boy. All six lasat mice, inoculated with 6 × 10^6 to 1 × 10^7 cells subcutaneously, developed permanently growing tumors which were strikingly similar to the parent tumor. In paraffin sections the transplanted tumor tissue was of high cellularity and showed perivascular arrangement of tumor cells with marked endothelial proliferation, mitotic figures, and small necrotic foci. Invasive proliferation of the tumor cells beyond the proper connective tissue capsule of the mouse was also noted. Under electron microscopy tumor cells in the mice, similar to the cell line, retained a large amount of glial filaments measuring 9-10 nm in diameter. In an immunodiffusion study, the cell line and the tumors in mice showed a precipitation line with rabbit immune serum against purified glial fibrillary acidic protein.
- 日本脳神経外科学会の論文
- 1980-07-15
著者
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Yamashita Masafumi
Department Of Physics Tokyo University Of Science
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KITAMURA Katsutoshi
Department of Neurosurgery, Neurological Institute, Kyushu University
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TAKAKI Tosuke
Department of Neurosurgery, Neurological Institute, Kyushu University
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TAKESHITA Iwao
Departments of Neurosurgery, Neurological Institute, Faculty of Medicine, Kyushu University
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Takaki Tosuke
Departments Of Neurosurgery Neurological Institute Faculty Of Medicine Kyushu University
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Takaki Tosuke
Department Of Neurosurgery Faculty Of Medicine Kyushu University
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Takeshita I
九州労災病院
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Takeshita Iwao
Department Of Neurosurgery Faculty Of Medicine Kyushu University
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Kitamura Katsutoshi
Departments Of Neurosurgery Neurological Institute Faculty Of Medicine Kyushu University
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Kitamura Katsutoshi
Department Neurosurgery Kyushu University
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OHTA Michiya
Department of Neuropathology, Neurological Institute, Faculty of Medicine, Kyushu University
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Ohta Michiya
Department Of Neuropathology Neurological Institute Faculty Of Medicine Kyushu University
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Ohta Michiya
Department Of Neurology Hiroshima Red Cross Hospital
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Yamashita Masafumi
Department Of Computer Science And Communication Engineering Kyushu University
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Yamashita Masafumi
Department Of Neurosurgery Neurological Institute Faculty Of Medicine Kyushu University
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