Expression of the B-chain of Platelet-derived Growth Factor and Proliferative Activity of Human Brain Tumors
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概要
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The expression of the B-chain of platelet-derived growth factor (PDGF) was analyzed in 29 human brain tumors (4 astrocytomas, 7 glioblastomas, 3 medulloblastomas, 3 oligodendrogliomas, 7 meningiomas, and others) using monoclonal antibody after digestion with alkaline phosphatase, and compared with proliferative activities measured by in vivo uptake of bromodeoxyuridine. Medullo-blastomas contained the highest amounts of PDGF B-chain, some four to eight times more than that in control brain tissue. The most predominant PDGF molecule of the medulloblastoma was 17kd. Astrocytomas, glioblastomas, oligodendrogliomas, and meningiomas contained predominantly 30 and/or 22-24 kd molecules. Glioblastoma and meningioma proliferative activities correlated closely to PDGF concentrations, with only a few exceptions. Tumors that contained a high level of PDGF B-chain showed high proliferative activity, while tumors with high proliferative activity did not always contain a high level of PDGF B-chain. Tumors that contain many PDGF B-chains may thus indicate malignancy.
- 日本脳神経外科学会の論文
- 1993-04-15
著者
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Fukui Masashi
Department Of Neurosurgery Kyushu University Faculty Of Medicine
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Fukui Masashi
Department Of Neurosurgery Graduate School Of Medical Science Kyushu University
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Takeshita I
九州労災病院
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Takeshita Iwao
Department Of Neurosurgery Faculty Of Medicine Kyushu University
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Inamura Takanori
Department Of Neurosurgery Kyushu University Faculty Of Medicine
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Inamura Takanori
Department Of Neurosurgery Graduate School Of Medical Science Kyushu University
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NAKAMURA Takaharu
Department of Neurosurgery, Kyushu Rosai Hospital
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TASHIMA Takatoshi
Department of Neurosurgery, Hamanomachi Hospital
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Nakamura Takaharu
Department Of Neurosurgery Neurological Institute Faculty Of Medicine Kyushu University:m.d. Departm
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Nakamura Takaharu
Department Of Neurosurgery Kyushu Rosai Hospital
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Tashima Takatoshi
Department Of Neurosurgery Hamanomachi Hospital
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Fukui Masashi
Department Of Neurosurgery Neurological Institute Graduate School Of Medical Sciences Kyushu Univers
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Fukui Masashi
Departments Of Neurosurgery Neurological Institute Faculty Of Medicine Kyushu University
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Fukui Masashi
Department Of Neurosurgery Faculty Of Medicine Kyushu University
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