Primary Pineal Yolk Sac Tumor : Ultrastructural and Immunohistochemical Features : Case Report
スポンサーリンク
概要
- 論文の詳細を見る
In an autopsy of a 16-year-old female with a primary intracranial yolk sac tumor (endodermal sinus tumor), histological evaluation of the surgical specimen obtained from the pineal region showed proliferation of undifferentiated neoplastic embryonal cells without characteristic histological features, such as periodic acid-Schiff-positive hyaline droplets or Schiller-Duval bodies. Ultrastructural study of the tumor cells, however, revealed typical cytological features of yolk sac tumor, including a voluminous, homogeneous, basement membrane-like substance, both within and outside of the cells, and intracytoplasmic vesicles containing amorphous material. Alpha-fetoprotein was detected in serum and cerebrospinal fluid by radioimmunoassay and within tumor tissues by immunohistochemical techniques. After surgery, chemotherapy with cis-diamminedichloroplatinum (II), vinblastine, and bleomycin was employed without significant benefit, and the patient died 5 months after tumor removal. Histological examination of the tumor at autopsy supported the diagnosis of yolk sac tumor. Electron microscopic and immunohistochemical studies of germ cell tumors are discussed.
- 日本脳神経外科学会の論文
- 1986-07-15
著者
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IWAKI Toru
Department of Materials Science, Graduate School of Engineering, Tohoku University
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KITAMURA Katsutoshi
Department of Neurosurgery, Neurological Institute, Kyushu University
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FUKUI Masashi
Departments of Neurosurgery, Neurological Institute, Faculty of Medicine, Kyushu University
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Iwaki T
Department Of Neuropathology Neurological Institute Graduate School Of Medical Sciences Kyushu Unive
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Iwaki Toru
Department Of Materials Science Graduate School Of Engineering Tohoku University
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Fukui Masashi
Department Of Neurosurgery Kyushu University Faculty Of Medicine
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Fukui Masashi
Department Of Neurosurgery Graduate School Of Medical Science Kyushu University
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NISHIO Shunji
Department of Neurosurgery,Neurological Institute,Kyushu University
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MORIOKA Takato
Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University
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Kitamura Katsutoshi
Departments Of Neurosurgery Neurological Institute Faculty Of Medicine Kyushu University
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Kitamura Katsutoshi
Department Neurosurgery Kyushu University
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Fukui Masashi
Department Of Neurosurgery Neurological Institute Graduate School Of Medical Sciences Kyushu Univers
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Nishio Shunji
Department Of Neurosurgery Neurological Institute Kyushu University
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Nishio Shunji
Department Of Neurosurgery Graduate School Of Medical Sciences Kyushu University
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Morioka Takato
Department Of Neurosurgery Neurological Institute Kyushu University
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Morioka Takato
Department Of Neurosurgery Faculty Of Medicine Kyushu University
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Morioka T
Department Of Neurosurgery Graduate School Of Medical Sciences Kyushu University
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Nishio Shunji
Department Of Neurosurgery Kyushu University
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Fukui Masashi
Department Of Neurosurgery Neurological Institute Graduate School Of Medical Sciences Kyushu Univers
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Fukui Masashi
Departments Of Neurosurgery Neurological Institute Faculty Of Medicine Kyushu University
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Fukui Masashi
Department Of Neurosurgery Faculty Of Medicine Kyushu University
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Iwaki Toru
Department of Chemistry, Faculty of Science, Hiroshima University
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