Ultrastructural and Cytochemical Study of Microvascular Enzyme Activity in Experimental Brain Tumors of Rat
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概要
- 論文の詳細を見る
We studied the fine structure and ultracytochemical features of microvessels of both normal rat cerebrum and brain tumors transplanted into rats. Ultrastructurally, the endothelial cells of the tumor vessels showed alterations, compared to those of normal vessels, such as attenuation, thickening, and/or abnormal endothelial junctions. In the control rats, an ultracytochemical study revealed alkaline phosphatase (AlPase) and adenosine triphosphatase (ATPase) activities were located mainly on the luminal plasma membrane of the endothelial cells, and 5'-nucleotidase (5'-N) activity on the abluminal plasma membrane. In the transplanted brain tumors, the sites of AlPase and 5'-N activities were similar to those of the controls, but the extent of the reactions on the abluminal and luminal membranes of the endothelial cells was greater. ATPase activity occurred mainly on the luminal plasma membrane of the endothelial cells in the controls, and on the abluminal membrane in the transplanted brain tumors. The number of pinocytotic vesicles showing positive reactions for AlPase, 5'-N, and ATPase was not higher in the tumor vessels than in the normal vessels. The redistribution of membrane enzymes in the endothelial cells of the transplanted brain tumors is presumed to be related at least partly to the changes in the endothelial junction.
- 日本脳神経外科学会の論文
- 1986-07-15
著者
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KITAMURA Katsutoshi
Department of Neurosurgery, Neurological Institute, Kyushu University
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EGAMI Hiroto
Departments of Neurosurgery, Neurological Institute, Faculty of Medicine, Kyushu University
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FUKUI Masashi
Departments of Neurosurgery, Neurological Institute, Faculty of Medicine, Kyushu University
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Egami Hiroto
Departments Of Neurosurgery Neurological Institute Faculty Of Medicine Kyushu University
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Fukui Masashi
Department Of Neurosurgery Kyushu University Faculty Of Medicine
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Fukui Masashi
Department Of Neurosurgery Graduate School Of Medical Science Kyushu University
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NISHIO Shunji
Department of Neurosurgery,Neurological Institute,Kyushu University
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Kitamura Katsutoshi
Departments Of Neurosurgery Neurological Institute Faculty Of Medicine Kyushu University
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Kitamura Katsutoshi
Department Neurosurgery Kyushu University
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Sawa Hiroki
Department Of Neuropathology Neurological Institute Graduate School Of Medical Sciences Kyushu Unive
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Sawa Hiroki
Departments Of Neuropathology Neurological Institute Faculty Of Medicine Kyushu University
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Nishio Shunji
Department Of Neurosurgery Neurological Institute Kyushu University
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Nishio Shunji
Department Of Neurosurgery Graduate School Of Medical Sciences Kyushu University
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Nishio Shunji
Department Of Neurosurgery Kyushu University
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Fukui Masashi
Department Of Neurosurgery Neurological Institute Graduate School Of Medical Sciences Kyushu Univers
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Fukui Masashi
Departments Of Neurosurgery Neurological Institute Faculty Of Medicine Kyushu University
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Fukui Masashi
Department Of Neurosurgery Faculty Of Medicine Kyushu University
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