Antitubercular Activity and Inhibitory Effect on Epstein-Barr Virus Activation of Sterols and Polyisoprenepolyols from an Edible Mushroom, Hypsizigus marmoreus(Pharmacognosy)

スポンサーリンク

概要

• 論文の詳細を見る

• Seven sterols (1-7) and eight polyisoprenepolyols (8-15), isolated from the non-saponifiable lipid fraction of the dichloromethane extract of an edible mushroom, Hypsizigus marmoreus (Buna-shimeji), were tested for their antitubercular activity against Mycobacterium tuberculosis strain H_<37>Rv using the Microplate Alamar Blue Assay (MABA). Six sterols (2-7) and two polyisoprenepolyols (8, 12) showed a minimum inhibitory concentration (MIC) in the range of 1-51μg/ml, while the others (1, 9-11, 13-15) were inactive (MIC>128μg/ml). The seven sterols (1-7) and three polyisoprenepolyols (8, 10, 12) were further evaluated for their inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells. Sterols 6 and 7 showed potent inhibitory effects while preserving the high viability of Raji cells.

• 公益社団法人日本薬学会の論文
• 2005-06-01

著者

• FRANZBLAU Scott

  Institute for Tuberculosis Research, College of Pharmacy, University of Illinois at Chicago

• Suzuki Takashi

  College of Pharmacy, Nihon University

• Akihisa Toshihiro

  College of Science and Technology, Nihon University

• Motani Kou

  日本大学 薬学部臨床医学ユニット

• Suzuki T

  Department Of Biochemistry University Of Shizuoka School Of Pharmaceutical Sciences:core Research Fo

• Kimura Y

  Coll. Of Pharmacy Nihon Univ.

• Kimura Yumiko

  College Of Pharmacy Nihon University

• YASUKAWA Ken

  College of Pharmacy, Nihon University

• Suzuki T

  Department Of Pharmaceutics College Of Pharmacy Nihon University

• Suzuki Takashi

  School Of Pharmacy Nihon Univ.

• TOKUDA Harukuni

  Kyoto Prefectural University of Medicine

• Metori Koichi

  Chemical Analytical Center College Of Pharmacy Nihon University

• Metori Koichi

  College Of Pharmacy Nihon University

• Metori Koichi

  Coll. Of Pharmacy Nihon Univ.

• UKIYA Motohiko

  College of Science and Technology, Nihon University

• Yasukawa Ken

  Coll. Of Pharmacy Nihon Univ.

• Yasukawa Ken

  College Of Pharmacy Nihon University

• Akihisa T

  College Of Pharmacy Nihon University

• Akihisa Toshihiro

  日本大学 理工学部

• Akihisa Toshihiro

  College Of Science And Technology Nihon University

• Tokuda Harukuni

  Dep. Of Complementary And Alternative Medicine Clinical R&d Graduate School Of Medical Sci. Kana

• Ukiya Motohiko

  College Of Science And Technology Nihon University

• Suzuki Takashi

  Department Of Biochemistry University Of Shizuoka School Of Pharmaceutical Sciences:core Research Fo

• TOKUDA Harukuni

  C 964), University of Illinois at Chicago

• TAGATA Masaaki

  Department of Biochemistry and Molecular Biology, Kyoto Prefectural University of Medicine

• MATSUZAWA Tsunetomo

  College of Science and Technology, Nihon University

• METORI Koichi

  Agricultural Technology Institute of Nagano Farmers' Federation

• Tagata Masaaki

  Department Of Biochemistry And Molecular Biology Kyoto Prefectural University Of Medicine

• Franzblau Scott

  Institute For Tuberculosis Research College Of Pharmacy (m

• Matsuzawa Tsunetomo

  College Of Science And Technology Nihon University

• Takase S

  College Of Science And Technology (funabashi Campus) Nihon University

関連論文

• Albanol A from the Root Bark of Morus alba L. Induces Apoptotic Cell Death in HL60 Human Leukemia Cell Line
• Identification and Characterization of Carbohydrate Molecules in Mammalian Cells Recognized by Dengue Virus Type 2
• A Unique Phosphatidylinositol Bearing a Novel Branched-Chain Fatty Acid from Rhodococcus equi Binds to Influenza Virus Hemagglutinin and Inhibits the Infection of Cells
• lnhibitory action of sulfatide a putative ligand for L-selectiv on B cell proliferation and lg prodrction
• Synergistic Effect of Isopropyl Myristate and Glyceryl Monocaprylate on the Skin Permeation of Pentazocine
• Inhibitory Effect of Some Oxygenated Stigmastane-Type Sterols on 12-O-Tetradecanoylphorbol-13-acetate-Induced Inflammation in Mice
• Structures of Five Hydroxylated Sterols from the Seeds of Trichosanthes kirilowii MAXIM.
• Five D : C-Friedo-Oleanane Triterpenes from the Seeds of Trichosanthes kirilowii MAXIM. and Their Anti-inflammatory Effects
• Inhibitory Effect of Karounidiol on 12-O-Tetradecanoylphorbol-13-acetate-Induced Tumor Promotion
• Antitubercular triterpenes and phytosterols from Pandanus tectorius Soland. var. laevis
• Recognition of N-Glycolylneuraminic Acid Linked to Galactose by the α2,3 Linkage Is Associated with Intestinal Replication of Influenza A Virus in Ducks
• In Vitro Inhibition of Human Influenza A Virus Infection by Fruit-Juice Concentrate of Japanese Plum (Prunus mume SIEB. et ZUCC)(Microbiology)
• Clarithromycin Inhibits Progeny Virus Production from Human Influenza Virus-Infected Host Cells(Microbiology)
• Suppression of the Biosynthesis of Cellular Sphingolipids Results in the Inhibition of the Maturation of Influenza Virus Particles in MDCK Cells(Highlighted paper selected by Editor-in-chief,Biochemistry)
• In Vitro and in Vivo Inhibitory Effects of Disodium Cromoglycate on Influenza Virus Infection(Pharmacology)
• Duck and Human Pandemic Influenza A Viruses Retain Sialidase Activity under Low pH Conditions^1
• Ganglioside GM_ on the Cell Surface Is Involved in the Infection by Human Rotavirus KUN and MO Strains
• The Melanogenesis-Inhibitory, Anti-Inflammatory, and Chemopreventive Effects of Limonoids in n-Hexane Extract of Azadirachta indica A. Juss. (Neem) Seeds
• 4-Hydroxyderricin from Angelica keiskei Roots Induces Caspase-dependent Apoptotic Cell Death in HL60 Human Leukemia Cells
• Survivin as a Prognostic Factor for Osteosarcoma Patients
• Cytotoxic activity of Perilla frutescens var. japonica leaf extract is due to high concentrations of oleanolic and ursolic acids
• Proteomic Analysis of Apoptosis Induced by Xanthoangelol, a Major Constituent of Angelica keiskei, in Neuroblastoma(Pharmacology)
• Isobavachalcone, a Chalcone Constituent of Angelica keiskei, Induces Apoptosis in Neuroblastoma(Pharmacology)
• A Novel Cyclophane Compound, CPPy, Facilitates NGF-Induced TrkA Signal Transduction and Induces Cell Differentiation in Neuroblastoma(Molecular and Cell Biology)
• Cancer Chemopreventive Effects and Cytotoxic Activities of the Triterpene Acids from the Resin of Boswellia carteri(Pharmacognosy)
• Xanthoangelol, a Major Chalcone Constituent of Angelica keiskei, Induces Apoptosis in Neuroblastoma and Leukemia Cells(Pharmacology)
• P-564 MULTI-DIMENSIONAL HPLC MAPPING METHOD FOR STRUCTURAL ANALYSES OF N-GLYCANS AND ITS APPLICATIONS TO N-GLYCOSYLATION PROFILING OF ORGANISMS AND TISSUES
• Studies on the Constituents of Fruits of Helicteres isora L.
• Enhancement of Water Solubility of Fullerene by Cogrinding with Mixture of Cycloamyloses, Novel Cyclic α-1,4-Glucans, via Solid-Solid Mechanochemical Reaction
• Sulfatide and Its Synthetic Analogues Recognition by Moraxella catarrhalis
• β-Thujaplicin Zinc Chelate Induces Apoptosis in Mouse High Metastatic Melanoma B16BL6 Cells
• Inhibitory effect of the rhizomes of Alpinia officinarum on TPA-induced inflammation and tumor promotion in two-stage carcinogenesis in mouse skin
• Development of acute lymphoblastic leukemia following hemophagocytic lymphohistiocytosis : is it secondary leukemia ?
• 6S, 8R-Stereochemistry of the C_- and C_-Alkane-6,8-diols Isolated from Three Compositae Flowers
• Useful Markers for Detecting Minimal Residual Disease in Cases of Neuroblastoma(Molecular and Cell Biology)
• Treatment of Ewing's Sarcoma Using an Antisense Oligodeoxynucleotide to Regulate the Cell Cycle(Molecular and Cell Biology)
• Analyses of Novel Prognostic Factors in Neuroblastoma Patients(Molecular and Cell Biology)
• Significance of Survivin mRNA Expression in Prognosis of Neuroblastoma(Analytical Biochemistry)
• Usefulness of Tyrosine Hydroxylase mRNA for Diagnosis and Detection of Minimal Residual Disease in Neuroblastoma (Biochemistry/Molecular Biology)
• Diagnostic Significance and Clinical Applications of Chimeric Genes in Ewing's Sarcoma
• Effect of Permeation Enhancers on the in Vitro Percutaneous Absorption of Pentazocine(Biopharmacy)
• Clusia guaviarensisからの新規トリテルペノイド(17α,20R)-Dammara-12,24-dien-3β-ol
• Detection of Chimeric Genes in Ewing's Sarcoma and Its Clinical Applications
• Three New Cyclic Diarylheptanoids and Other Phenolic Compounds from the Bark of Myrica rubra and Their Melanogenesis Inhibitory and Radical Scavenging Activities
• Melanogenesis Inhibitory and Free Radical Scavenging Activities of Diarylheptanoids and Other Phenolic Compounds from the Bark of Acer nikoense(Pharmacognosy)
• Anti-inflammatory and Antitumor-Promoting Effects of the Triterpene Acids from the Leaves of Eriobotrya japonica(Pharmacognosy)
• Triterpene Acids from the Leaves of Perilla frutescens and Their Anti-inflammatory and Antitumor-promoting Effects
• Molecular Complex Consisting of Two Typical External Medicines: Intermolecular Interaction between Indomethacin and Lidocaine
• Granuloma Maturation in the Rat is Advanced by the Oral Administration of Eucommia ulmoides OLIVER Leaf
• The Promoting Effect of Eucommiol from Eucommiae Cortex on Collagen Synthesis
• Improvement in the Turnover Rate of the Stratum Corneum in False Aged Model Rats by the Administration of Geniposidic Acid in Eucommia ulmoides OLIVER Leaf
• Formulation and in Vitro Evaluation of Pentazocine Transdermal Delivery System(Biopharmacy)
• Quantitative Investigation of the Effect of Sensory Nerve Anesthesia with 9% Lidocaine Ointment on Healthy Subjects by Use of the Neuroselective Current Perception Threshold
• Dissolution Tests for Self-Setting Calcium Phosphate Cement-Containing Nifedipine
• 3-O-(E)-p-Coumaroyl Tormentic Acid from Eriobotrya japonica Leaves Induces Caspase-Dependent Apoptotic Cell Death in Human Leukemia Cell Line
• Anti-Inflammatory and Chemopreventive Effects of Triterpene Cinnamates and Acetates from Shea Fat
• Inhibitory Effect of Cycloartenol Ferulate, a Component of Rice Bran, on Tumor Promotion in Two-Stage Carcinogenesis in Mouse Skin
• Triterpene Alcohols from Camellia and Sasanqua Oils and Their Anti-inflammatory Effects
• 4-Epicycloeucalenone and 4-Epicyclomusalenone : Two 3-Oxo-28-norcycloartanes from the Fruit Peel of Musa sapientum L.
• Cyclokirilodiol and Isocyclokirilodiol : Two Novel Cycloartanes from the Seeds of Trichosanthes kirilowii MAXIM.
• Inhibitory Effect of Di- and Trihydroxy Triterpenes from the Flowers of Compositae on 12-O-Tetradecanoylphorbol-13-acetate-Induced Inflammation in Mice
• Helianol [3,4-seco-19(10→9)abeo-8α, 9β, 10α-eupha-4,24-dien-3-ol], a Novel Triterpene Alcohol from the Tabular Flowers of Helianthus annuus L.
• Eight Novel Sterols from the Roots of Bryonia dioica JACQ.
• Inhibitory Effects of Sterols Isolated from Chlorella vulgaris on 12-O-Tetradecanoylphorbol-13-acetate-Induced Inflammation and Tumor Promotion in Mouse Skin
• Investigation on the Influx Transport Mechanism of Pentazocine at the Blood-Brain Barrier in Rats Using the Carotid Injection Technique(Biopharmacy)
• Pharmacokinetic/Pharmacodynamic Relationship of Eptazocine, a Narcotic-Antagonist Analgesic, in Rats
• Change of β-Endorphin Concentration in Rat Brain after Administration of Indomethacin or Carrageenin
• Pharmacokinetics of Pentazocine and Its Occupancy of Opioid Receptors in Rat Brain
• Relationship between Pharmacokinetics and the Analgesic Effect of Indomethacin in the Rat
• Differential Effects of Buprenorphine and Pentazocine on the Regional Cerebral Metabolic Rate for Glucose in the Conscious Rat
• Involvement of P-glycoprotein in Blood-Brain Barrier Transport of Pentazocine in Rats Using Brain Uptake Index Method(Biopharmacy)
• 3-Epicabraleahydroxylactone and Other Triterpenoids from Camellia Oil and Their Inhibitory Effects on Epstein-Barr Virus Activation
• The Promoting Effects of Geniposidic Acid and Aucubin in Eucommia ulmoides OLIVER Leaves on Collagen Synthesis
• Acerogenin M, a Cyclic Diarylheptanoid, and Other Phenolic Compounds from Acer nikoense and Their Anti-inflammatory and Anti-tumor-Promoting Effects
• Antitubercular Activity and Inhibitory Effect on Epstein-Barr Virus Activation of Sterols and Polyisoprenepolyols from an Edible Mushroom, Hypsizigus marmoreus(Pharmacognosy)
• Antitubercular Activity of Triterpenoids from Asteraceae Flowers(Pharmacognosy)
• Inhibitory effects of falconensins on 12-O-tetradecanoylphorbol-13-acetate-induced inflammatory ear edema in mice
• Triterpene Alcohol and Fatty Acid Composition of Shea Nuts from Seven African Countries
• Melanogenesis Inhibitory Activities of Iridoid-, Hemiterpene-, and Fatty Acid-glycosides from the Fruits of Morinda citrifolia (Noni)
• Melanogenesis Inhibitory, Anti-Inflammatory, and Chemopreventive Effects of Limonoids from the Seeds of Azadirachta indicia A. Juss. (Neem)
• A novel DNA topoisomerase inhibitor : dehydroebriconic acid, one of the lanostane-type triterpene acids from Poria cocos
• Dehydrotrametenonic Acid and Dehydroeburiconic Acid from Poria cocos and Their Inhibitory Effects on Eukaryotic DNA Polymerase α and β
• Astertarone A : A Triterpenoid Ketone Isolated from the Roots of Aster tataricus L.
• Inhibitory Effect of Stevioside on Tumor Promotion by 12-O-Tetradecanoylphorbot-13-acetate in Two-Stage Carcinogenesis in Mouse Skin
• Astertarone B, a Hydroxy-Triterpenoid Ketone from the Roots of Aster tataricus L.
• Cycloarta-16,24-dien-3β-ol : Revised Structure of Cimicifugenol, a Cycloartane Triterpenoid
• Powdered formulation of liquid oil terpenoid included in cyclodextrins for chemical stabilization and improved handling
• Effect of the Opioid Antagonist Naloxone on the Regional Metabolic Rate for Glucose in the Conscious Rat Brain
• Studies on the Constituents of the Leaves of Morus alba L.
• Measurement of Inclusion Complex Formation between Cyclophane and Biological Relevant Amino Acids Using Electrospray Ionization, Cold-Spray Ionization and Fast Atom Bombardment Mass Spectrometry
• Determination of Association Constant of Inclusion Complex between Cyclophane and Biological Relevant Phosphates by Fast Atom Bombardment Mass Spectrometry
• Proof of Inclusion Complex Formation between Cyclophane and Aromatic Guests by Fast Atom Bombardment Mass Spectrometry
• P-470 HIGHLY OXYGENATED CYCLOHEXENES FROM UVARIA RUFA
• Antiviral activities of diarylheptanoids against influenza virus in vitro
• Unique heparan sulfate from shrimp heads exhibits a strong inhibitory effect on infections by dengue virus and Japanese encephalitis virus
• Induction of Apoptosis in Human Leukemia Cell (Jurkat) by Neolignans Isolated from Seeds of Licaria puchury-major
• Ferrearin C induces apoptosis via heme oxygenase-1 (HO-1) induction in neuroblastoma
• Evaluation of the Degree of Mixing of Combinations of Dry Syrup, Powder, and Fine Granule Products in Consideration of Particle Size Distribution Using Near Infrared Spectrometry
• Vitamin K3 Analogs Induce Selective Tumor Cytotoxicity in Neuroblastoma
• The Inhibition of Human Tumor Cell Proliferation by RNase Pol, a Member of the RNase T1 Family, from Pleurotus ostreatus

もっと見る 閉じる

スポンサーリンク