Inhibitory Effect of Di- and Trihydroxy Triterpenes from the Flowers of Compositae on 12-O-Tetradecanoylphorbol-13-acetate-Induced Inflammation in Mice

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概要

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• Ten dihydroxy- and trihydroxy triterpenes, viz., four taraxastanes : faradiol, heliantriol B_0,heliantriol C and arnidiol; two lupanes : calenduladiol and heliantriol B_2; two oleananes : maniladiol and longispinogenin; and two ursanes : brein and uvaol, isolated from the nonsaponifiable lipids of the flower extracts of Compositae plants were evaluated with respect to their anti-inflammatory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice. All the triterpenes were found to possess marked inhibitory activity. The 50% inhibitory dose of these compounds with respect to TPA-inflammation (1 μg) was 0.03-0.2 mg/ear.

• 公益社団法人日本薬学会の論文
• 1996-10-15

著者

• Akihisa Toshihiro

  College of Science and Technology, Nihon University

• Kimura Y

  Coll. Of Pharmacy Nihon Univ.

• Kimura Yumiko

  College Of Pharmacy Nihon University

• YASUKAWA Ken

  College of Pharmacy, Nihon University

• TAKIDO Michio

  College of Pharmacy, Nihon University

• Yasukawa Ken

  Coll. Of Pharmacy Nihon Univ.

• Yasukawa Ken

  College Of Pharmacy Nihon University

• Akihisa Toshihiro

  College Of Science And Technology Nihon University

• Tai Takaaki

  Morishita Jintan Co. Ltd.

• Takido M

  College Of Pharmacy Nihon University

• Takido Michio

  College Of Pharmacy Nihon University

• Tamura T

  Department Of Chemistry And Chemical Engineering Faculty Of Engineering Yamagata University

• YAMANOUCHI Shizuka

  Department of Pharmaceutics, Showa College of Pharmaceutical Sciences

• TAMURA Toshitake

  College of Science and Technology, Nihon University

• YAMANOUCHI Sakae

  College of Pharmacy, Nihon University

• OINUMA Hirotoshi

  College of Science and Technology, Nihon University

• KASAHARA Yoshimasa

  The Yamagata Prefectural Institute of Public Health

• KUMAKI Kunio

  The Yamagata Prefectural Institute of Public Health

• Yamanouchi S

  Department Of Pharmaceutics Showa College Of Pharmaceutical Sciences

• Okuda Hiroki

  College Of Science And Technology Nihon University

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