Anti-Inflammatory and Chemopreventive Effects of Triterpene Cinnamates and Acetates from Shea Fat
スポンサーリンク
概要
- 論文の詳細を見る
Four triterpene acetates, α-amyrin acetate (1a), β-amyrin acetate (2a), lupeol acetate (3a), and butyrospermol acetate (4a), and four triterpene cinnamates, α-amyrin cinnamate (1c), β-amyrin cinnamate (2c), lupeol cinnamate (3c), and butyrospermol cinnamate (4c), were isolated from the kernel fat (n-hexane extract) of the shea tree (Vitellaria paradoxa; Sapotaceae). Upon evaluation of these eight triterpene esters for inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation (1 μg/ear) in mice, all of the compounds tested exhibited marked anti-inflammatory activity, with ID50 values in the range of 0.15–0.75 μmol/ear, and among which compound 3c showed the highest activity with ID50 of 0.15 μmol/ear. Compound 3c (10 mg/kg) further exhibited anti-inflammatory activity on rat hind paw edema induced by carrageenan, with the percentage of inflammation at 1, 3, and 5 h of 35.4, 41.5, and 45.5%, respectively. The eight triterpene esters were then evaluated for their inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) in Raji cells as a primary screening test for inhibitors of tumor promoters. All the compounds showed moderate inhibitory effects. Furthermore, compound 3c exhibited inhibitory effect on skin tumor promotion in an in vivo two-stage carcinogenesis test using 7,12-dimethylbenz [a] anthracene (DMBA) as an initiator and TPA as a promoter. The biological activities of triterpene acetate and cinnamate esters, together with the exceptionally high levels of these triterpenes in shea fat, indicate that shea nuts and shea fat (shea butter) constitute a significant source of anti-inflammatory and anti-tumor promoting compounds.
- 日本油化学会の論文
著者
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Tabata Keiichi
日本大学 薬学部臨床医学ユニット
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T. Masters
World Agroforestry Centre (icraf)
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Kikuchi Takashi
College of Science and Technology, Nihon University
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Akihisa Toshihiro
College of Science and Technology, Nihon University
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TOKUDA Harukuni
Department of Molecular Biochemistry, Kyoto Prefectural University of Medicine
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YASUKAWA Ken
College of Pharmacy, Nihon University
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Yasukawa Ken
College Of Pharmacy Nihon University
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Akihisa T
College Of Pharmacy Nihon University
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Akihisa Toshihiro
日本大学 理工学部
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Akihisa Toshihiro
College Of Science And Technology Nihon University
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Manosroi Aranya
Faculty of Pharmacy, Chiang Mai University
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Manosroi Jiradej
Faculty of Pharmacy, Chiang Mai University
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Tokuda Harukuni
Department Of Biochemistry And Molecular Biology Kyoto Prefectural University Of Medicine
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Kojima Nobuo
College of Science and Technology, Nihon University
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Manosroi Aranya
Faculty Of Pharmacy Chiang Mai University
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Tabata Keiichi
School Of Pharmacy Nihon University
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Tokuda Harukuni
Department of Complementary and Alternative Medicine, Clinical R&D, Graduate School of Medical Science, Kanazawa University
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