Epstein-Barr Virus Early Antigen Inducing Activity of 14-O-Derivatives of (-)-Indolactam V
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概要
- 論文の詳細を見る
New 14-O-derivatives of (-)-indolactam V, which has the basic ring-structure of teleocidins without the monoterpenoid moiety, were prepared and their Epstein-Barr virus early antigen (EBV-EA) inducing activity was tested. A series of 14-O-alkyl derivatives was far less active than (-)-indolactam V, but the 14-O-acyl derivatives showed a high EBV-EA inducing activity. These results suggest that the free hydroxyl group at C-14 plays an important role in inducing the EBV-EA, and that the activity of the acyl derivatives arises through hydrolysis of the ester groups.
- 社団法人 日本農芸化学会の論文
著者
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Irie Kazuhiro
Department Of Food Science And Technology Faculty Of Agriculture Kyoto University
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Koshimizu Koichi
Department Of Biotechnological Science Faculty Of Biology-oriented Science And Technology Kinki Univ
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HAGIWARA Nobuyuki
Department of Food Science and Technology, Faculty of Agriculture, Kyoto University
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HAYASHI Hideo
College of Agriculture, University of Osaka Prefecture
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MURAO Sawao
College of Agriculture, University of Osaka Prefecture
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Tokuda Harukuni
Department Of Biochemistry And Molecular Biology Kyoto Prefectural University Of Medicine
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IRIE Kazuhiro
Department of Food Science and Technology, Faculty of Agriculture, Kyoto University
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Ito Yohei
Department of Aeronautics and Astronautics, Kyushu University, Fukuoka 819-0395, Japan
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TOKUDA Harukuni
Department of Microbiology, Faculty of Medicine, Kyoto University
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