Selinidin Suppresses IgE-Mediated Mast Cell Activation by Inhibiting Multiple Steps of FcεRI Signaling(Pharmacology)

スポンサーリンク

概要

• 論文の詳細を見る

• IgE-mediated mast cell activation is critical for development of allergic inflammation. We have recently found that selinidin, one of the coumarin derivatives isolated from Angelica keiskei, attenuates mast cell degranulation following engagement of the high-affinity receptor for IgE (FcεRI) with IgE and antigen. In the present study, we investigated the effects of selinidin on intracellular signaling and mast cell activation employing bone marrow-derived mast cells. Here, we report that selinidin attenuates the release of β-hexosaminidase, synthesis of leukotriene C_4, and production of tumor necrosis factor-α without affecting IgE-FcεRI binding. Furthermore, biochemical analyses of the FcεRI-mediated signaling pathway demonstrated that selinidin decreases phosphorylation of phospholipase C-γ1, p38 mitogen-activated protein kinase, and iTCB-α upon FcεRI stimulation. These results suggest that this compound suppresses IgE-mediated mast cell activation by inhibiting multiple steps of FcεRI-dependent signaling pathways and would be beneficial for the prevention of allergic inflammation.

• 公益社団法人日本薬学会の論文
• 2008-03-01

著者

• RA Chisei

  Division of Molecular Cell Immunology and Allergology, Nihon University Graduate School of Medical S

• NAGAI Hisashi

  Department of Materials and Applied Chemistry, College of Science and Technology, Nihon University

• AKIHISA Toshihiro

  Department of Materials and Applied Chemistry, College of Science and Technology, Nihon University

• Nagai Hisashi

  Department Of Materials And Applied Chemistry Collegeof Science And Technology Nihon University

• Nagai Hisashi

  Department Of Electrical Engineering Kyoto University

• Ra Chisei

  Division Of Molecular Cell Immunology And Allergology Advanced Medical Research Center Nihon Univers

• Ra Chisei

  Division Of Molecular Cell Immunology And Allergology Nihon University Graduate School Of Medical Sc

• NUNOMURA Satoshi

  Division of Molecular Cell Immunology and Allergology, Nihon University Graduate School of Medical S

• Akihisa Toshihiro

  Department Of Materials And Applied Chemistry Collegeof Science And Technology Nihon University

• KISHIRO Sachiko

  Division of Molecular Cell Immunology and Allergology, Nihon University Graduate School of Medical S

• Kishiro Sachiko

  Division Of Molecular Cell Immunology And Allergology Nihon University Graduate School Of Medical Sc

• Ra Chisei

  Division Of Molecular Biology Allergy Research Center Juntendo University School Of Medicine

• Nunomura Satoshi

  Division Of Molecular Cell Immunology And Allergology Nihon University Graduate School Of Medical Sc

• Nunomura Satoshi

  Division Of Molecular Cell Immunology And Allergology Nihon University Graduate School Of Medical Sc

• Nunomura Satoshi

  Division Of Molecular Cell Immunology And Allergology Advanced Medical Research Center Nihon Univers

関連論文

• 1P115 高親和性lgE受容体β鎖変異体(D234A)の構造解析(膜蛋白質,第48回日本生物物理学会年会)
• Comparison of Topical Dexamethasone and Topical FK506 Treatment for the Experimental Allergic Conjunctivitis Model in Balb/c Mice
• Proteomic Analysis of Apoptosis Induced by Xanthoangelol, a Major Constituent of Angelica keiskei, in Neuroblastoma(Pharmacology)
• Isobavachalcone, a Chalcone Constituent of Angelica keiskei, Induces Apoptosis in Neuroblastoma(Pharmacology)
• Xanthoangelol, a Major Chalcone Constituent of Angelica keiskei, Induces Apoptosis in Neuroblastoma and Leukemia Cells(Pharmacology)
• Expression of Humanized Fab Fragments That Recognize the IgE-Binding Domain of Human FcεRIα in COS and CHO Cells
• 2P-081 高親和性IgE受容体β鎖C末端領域の構造解析(膜蛋白質,第47回日本生物物理学会年会)
• 3-O-(2,3-Dimethylbutanoyl)-13-O-decanoylingenol from Euphorbia kansui Suppresses IgE-Mediated Mast Cell Activation(Pharmacology)
• IgE- and FcεRI-mediated migration of human basophils
• IS1-2 Regulation of mast cell activation by FcεRIβ chain(Session 1: Effector and Immune Regulator Functions of Inflammatory Cells,Eosinophils, other Inflammatory Cells and Molecules in Allergy)
• Role of the FcεRI β-chain ITAM as a signal regulator for mast cell activation with monomeric IgE
• Surface Morphology of YBa_2Cu_3O_ Films Prepared by Metalorganic Chemical Vapor Deposition Using Liquid Sources
• Preparation of A-axis Oriented YBa_2Cu_3O_ Films by Metalorganic Chemical Vapor Deposition Using Liquid Sources
• Preparation of YBa_2Cu_3O_ Thin Films by Metal-Organic Chemical Vapor Deposition Using Liquid Sources
• Selinidin Suppresses IgE-Mediated Mast Cell Activation by Inhibiting Multiple Steps of FcεRI Signaling(Pharmacology)
• 3P-083 高親和性IgE受容体β鎖遺伝子多型の構造解析(膜蛋白質,第46回日本生物物理学会年会)
• 1P065 Structural study of mutated FcεRI β chain ITAM by CD spectroscopy(2. Protein function (I),Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)
• Analysis of the Mechanism for the Development of Allergic Skin Inflammation and the Application for Its Treatment : Aspirin Modulation of IgE-Dependent Mast Cell Activation : Role of Aspirin-Induced Exacerbation of Immediate Allergy
• IP-10 PAF causes degranulation via PLCβ2 activation in human mast cells
• Targeting Human Mast Cells Expressing G-Protein-Coupled Receptors in Allergic Diseases
• A BASH/SLP-76-related adaptor protein MIST/Clnk involved in lgE receptor-mediated mast cell degranulation
• Influence of light direction on appearance of solid object
• IS-4 The amplification mechanisms of FcεRIβ in the FcRγ-mediated human mast cells activation signal(Topics on IgE-FcεRI-Mast Cells)
• Development of Pyrrole–Imidazole Polyamide Targeting Fc Receptor Common Gamma Chain for the Treatment of Immune-Complex Related Renal Disease

もっと見る 閉じる

スポンサーリンク