Role of Reactive Oxygen Species in Gallic Acid-Induced Apoptosis
スポンサーリンク
概要
- 論文の詳細を見る
We earlier demonstrated that gallic acid (3,4,5-trihydroxybenzoic acid) induced apoptosis in promyelocytic leukemia HL-60RG cells, which was inhibited by catalase and intracellular Ca^<2+> chelator. In this study, we further studied the involvement of reactive oxygen species (ROS) and intracellular Ca^<2+> in gallic acid-induced apoptosis. The enhancement of intracellular ROS in HL-60RG cells was detected dose-dependently as early as 5 min after stimulation with gallic acid by using 5,6-carboxy-2', 7'-dichlorofluorescin diacetate (DCFH-DA). Further studies that used various antioxidants and ROS scavengers showed that the intracellular peroxide level was well correlated with the potency to induce apoptosis and that the increased intracellular peroxides after gallic acid treatment seemed likely to result from the influx of H_2O_2 derived from superoxide which were generated extracellularly. In addition, gallic acid, HX/XO, and H_2O_2-induced apoptosis was completely inhibited by pretreatment with intracellular Ca^<2+> chelator 1,2-bis(2-aminophenoxyethane)-N, N, N, N'-tetraacetic acid tetrakis (acetoxymethyl ester)(BAPTA-AM), but increase of intracellular peroxide levels by gallic acid were suppressed only slightly. It is suggested that intracellular ROS induced by gallic acid plays an important role in eliciting an early signal in apoptosis. Especially, H_2O_2 which is derived from superoxide anion generated extracellularly may increase intracellular Ca^<2+> levels or cooperate with intracellular Ca^<2+>, thus resulting in apoptosis induction.
- 公益社団法人日本薬学会の論文
- 2000-10-01
著者
-
Inoue Makoto
Department of Pediatrics, Shimane Medical University
-
Inoue M
Lab. Of Medicinal Resources School Of Pharmacy Aichi Gakuin Univ.
-
SAKAGUCHI Nahoko
Department of Biochemistry, Nagoya University School of Medicine
-
Ogihara Yukio
Laboratory Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Nagoya City University
-
Ogihara Yukio
Faculty Of Pharmacy Meijo Universitv
-
Ogihara Yukio
Department Of Pharmacognosy Faculty Of Pharmaceutical Sciences Nogoya City University
-
Ogihara Yukio
Department Of Pharmacognosy And Plant Chemistry Faculty Of Pharmaceutical Sciences Nagoya City Unive
-
Ogihara Yukio
Graduate School Of Pharmaceutical Sciences Nagoya City University
-
Inoue M
Laboratory Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Nagoya City University
-
ISUZUGAWA Kazuto
Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Nagoya City University
-
TANI Hiroyuki
Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Nagoya City University
-
Tani Hiroyuki
Department Of Pharmacognosy Faculty Of Pharmaceutical Sciences Nagoya City University
-
Isuzugawa Kazuto
Department Of Pharmacognosy Faculty Of Pharmaceutical Sciences Nagoya City University
-
Ogihara Y
Department Of Pharmacognosy And Plant Chemistry Faculty Of Pharmaceutical Sciences Nagoya City Unive
-
Sakaguchi N
Nagoya Univ. School Of Medicine Nagoya Jpn
-
Sakaguchi Nahoko
Department Of Biochemistry Nagoya University School Of Medicine
-
Inoue Makoto
Department Of Biological Chemistry Faculty Of Pharmaceutical Sciences Nagoya City University
-
Tani Hiroyuki
Department of Chemistry, Faculty of Science, Ehime University
関連論文
- Pilot study on neonatal mass screening for inborn errors of metabolism by gas chromatography-mass spectrometry : eighteen months experience in Shimane Area
- Successful relatively low-dose corticosteroid therapy for diclofenac-induced acute interstitial nephritis with severe renal failure
- Scattering of 34.4-MeV Alpha Particles by the Tin Isotopes
- Energy Spectra of Inelastic Scattering of 28.4-MeV Alpha Particles
- HPLC profiling of Phellinus linteus
- Receptor-type protein tyrosine phosphatase ζ as a component of the signaling receptor complex for midkine-dependent survival of embryonic neurons
- HDL_3 Exerts a More Powerful Antiperoxidative and Protective Effect against Peroxidative Modification of LDL than HDL_2 Does
- A survey of Japanese patients with mitochondrial fatty acid β-oxidation and related disorders as detected from 1985 to 2000
- Anti-atherosclerotic action of Saikokaryukotsuboreito against apoE-deficient mice
- Phenylethanoid and Iridoid Glycosides from Veronica persica
- New Phenylethanoid Glycosides from Veronica pectinata var. glandulosa and Their Free Radical Scavenging Activities
- Anti-inflammatory and Cytotoxic Activities of Five Veronica Species
- Induction of Cytokines by a Phenylpropanoid Glycoside Acteoside
- Enhancement of Serum Nitric Oxide by Shichimotsu-koka-to (Kampo Medicine)
- Induction of Apoptotic Cell Death in HL-60 Cells by Acteoside, A Phenylpropanoid Glycoside
- Serial magnetic resonance angiography in cerebral infarction after varicella infection
- Brain holding spells in early infancy
- Nonimmunologic fetal hydrops and chromosomal disorder : two cases of Down syndrome associated with hematopoietic abnormalities
- Trypanocidal Effects of Curcumin in Vitro
- Formation of Reactive Oxygen Intermediates Might be Involved in the Trypanocidal Activity of Gallic Acid
- Relaxation of Encircling Buckle Improved Choroidal Blood Flow in a Patient with Visual Field Defect Following Encircling Procedure
- Retinal Blood Flow in the Macular Area Before and After Scleral Buckling Procedures for Rhegmatogenous Retinal Detachment Without Macular Involvement
- Posterior Synechia of the Iris After Combined Pars Plana Vitrectomy, Phacoemulsification, and Intraocular Lens Implantation
- Catalase Contents in Cells Determine Sensitivity to the Apoptosis Inducer Gallic Acid
- Ca^-Dependent Caspase Activation by Gallic Acid Derivatives
- Latifolosides K and L, Two New Triterpenoid Saponins from the Bark of Ilex latifolia
- Latifolosides I and J, Two New Triterpenoid Saponins from the Bark of Ilex latifolia
- Sesquiterpene Lactone Suppresses Vascular Smooth Muscle Cell Proliferation and Migration via Inhibition of Cell Cycle Progression(Pharmacognosy)
- Management of complications after Partial hepatic resection in a hemodialysis patient with severe hepatomegaly caused by autosomal dominant polycystic kidney disease
- Changes in reflex responses of the masseter and digastric muscles during sleep in freely behaving rabbits
- Ardisimamillosides C-F, Four New Triterpenoid Saponins from Ardisia mamillata
- Repression of Acyl-CoA : Cholesterol Acyltransferase by a Traditional Herbal Medicine (Kampo Meidcine), Ogi-Keishi-Gomotsu-To-Ka-Kojin
- Antihyperlipidemic Action of Ogi-Keishi-Gomotsu-To-Ka-Kojin against Cyclophosphamide-Induced Hyperlipidemia in Rabbits
- Antihypercholesterolemic Action of a Traditional Chinese Medicine (Kampo Medicine), Ogi-Keichi-Gomotsu-To-Ka-Kojin
- Comparison of Cysteine and Serine Protease Inhibitors on Dynorphin B-Induced Antinociception in the Mouse Capsaicin Test
- Suppressive Effect of Kanzo-bushi-to, a Kampo Medicine, on Collagen-Induced Arthritis(Pharmacognosy)
- Suppressive Effect of Dai-bofu-to on Collagen-Induced Arthritis(Pharmacognosy)
- Evaluation of Kampo medicines used to treat rheumatoid arthritis in collagen-induced arthritic and pX transgenic mice
- Suppression of Macrophage Function by Substances with a Molecular Weight Lower than 3000 Da in B16 Melanoma-Conditioned Medium
- Suppressive Effect of Shichimotsu-koka-to (Kampo Medicine) on Pulmonary Metastasis of B16 Melanoma Cells
- Antimetastatic Activity of Acteoside, a Phenylethanoid Glycoside
- Inhibition of Cell Cycle Progression through Specific Phase by Pancratistatin Derivatives
- Cytotoxic activities of alkaloids from Zephyranthes carinata
- Different Generation of Inhibitors against Gallic Acid-Induced Apoptosis Produces Different Sensitivity to Gallic Acid
- Role of Reactive Oxygen Species in Gallic Acid-Induced Apoptosis
- Cell Death-Inducing Activity by Gallic Acid Derivatives
- Metabolic Fate of Gallic Acid Orally Administered to Rats
- Elastic and Inelastic Scattering of 28.4-MeV Alpha Particles by Sn, Cd, Ag, Cu and Ti
- Sulfated Triterpenoid Saponins from the Leaves of Bupleurum rotundifolium L.
- New Lignan Glycosides from Chinese Medicinal Plant, Sinopodophillum emodi
- A New Flavonol Glycoside, Epimedin K, From Epimedium koreanum
- PC7 STUDIES ON ACTIVE PRINCIPLES OF SOME CHINESE TRADITIONAL MEDICINES
- Flavonoids from Sinopodophyllum emodi (Wall) Ying
- Two New Podophyllotoxin Glucosides from Sinopodophyllum emodi (WALL.) YING
- Novel Biphenyl Ether Lignans from the Rhizomes of Curcuma chuanyujin
- Secondary Metabolism of Dinitrobenzyl Glucuronide Related to Production of Genotoxic Compounds of Dinitrotoluene in Male Wistar Rat
- Synthesis of Pyridinium Dinitrobenzyl Sulfates and Potassium (Dinitrobenzyl β-D-Glucopyranosid)Uronates
- Inhibitory effect of oral intake of natural Phellinus linteus fruit body on growth and pulmonary metastasis of B16/BL6 melanoma
- P-174 Low molecular weight constituents in Phellinus linteus
- Iridoid Glucosides from Veronica hederifolia
- An Elicitor-Inducible NADP-Malic Enzyme in Lithospermum erythrorhizon Cultured Cells : cDNA Cloning and Characterization
- Comparative Study of the High Molecular Mass Fraction and Low Molecular Mass Fraction of Sho-saiko-to in a Murine Immunologically Induced Liver Injury Model
- Synthesis of 2-O-(4-Coumaroyl)-3-(4-hydroxyphenyl)lactic Acid, an Important Intermediate of Rosmarinic Acid Biosynthesis
- Cloning and Bacterial Expression of Karasurins, Ribosome-Inactivating Proteins (RIPs) from Trichosanthes Kirilowii var. Japonica
- Three New Glycosides from Sinopodophyllum emodi (WALL.) YING
- A New N-Methyltetrahydroprotoberberine Alkaloid from Tinospora hainanensis
- -1096-COMPERATIVE EFFECTS OF NIFEDIOINE, BUNAZOSIN HYDROCHLORIDE OR BOTH ON HEMODYNAMICS IN MONOCLOTARINE INDUCED PULMONARY HYPERTENSION : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- THE SIGNIFICANCE OF PULMONARY ACCELERATION TIME IN CONGENITAL HEART DISEASE WITH LEFT TO RIGHT SHUNT : Pulmonary, Peripheral, Cerebral Circulation : 53 Annual Scientific Meeting, Japanese Circulation Society
- EFFECTS OF BUNAZOSIN HYDROCHLORIDE ON HEMODYNAMIC AND PATHOLOGICAL CHANGES IN RATS WITH PULMONARY HYPERTENSION INDUCED BY MONOCROTALINE : Cardiovascular Drugs : 53 Annual Scientific Meeting, Japanese Circulation Society
- Sesquiterpenoid Derivatives from Ferula ferulioides. IV
- Sequiterpenoid Derivatives from Ferula ferulioides. III
- Sesquiterpenoid Derivatives from Ferula ferulioides. II.
- Fuhsioside, a New Phenylethanoid Glucoside from Veronica fuhsii
- Xanthones from Halenia corniculata
- Sesquiterpenoid Derivatives from Ferula ferulioides
- LONG-TERM ADMINISTRATION OF "SHO-SAIKO-TO" INCREASES CYTOCHROME P-450 mRNA LEVEL IN MOUSE LIVER
- A New Phenylethanoid Glycoside from Phlomis pungens WILLD. var. pungens
- Tetranortriterpenoids from Swietenia macrophylla
- Absolute Structure of Eremophilenolide from Soligago dahurica
- Effect of Karasurin-A on Nitric Oxide Production by Murine Macrophages and Mitogenic Response of Murine Splenocytes in Vitro
- Peroxisome Proliferator-Activated Receptor γ Ligands Isolated from Adlay Seed(Coix lacryma-jobi L. var. ma-yuen STAPF)(Pharmacognosy)
- Phellifuropyranone A : A New Furopyranone Compound Isolated from Fruit Bodies of Wild Phellinus linteus
- ILVII-3 Kampo Medicines (Herbal Prescriptions in Japanese Traditional Medicine) as Molecular Library for Drug Development(Chemistry and Biochemistry Related to Biodiversity)
- Studies on Chemical Modification of Monensin IX. Synthesis of 26-Substituted Monensins and Their Na^+Ion Transport Activity
- The Effect of Keishi-bushi-to on Collagen-Induced Arthritis
- Effect of Shosaikoto (Kampo Medicine) on the Adherence of Monocytes in Hypercholesterolemic Rabbit
- Minor Saponins from Tetrapanax papyriferum
- Triterpene Saponins from Tetrapanax papyriferum K. KOCH
- Synthesis of Phenoxyacetic Acid Derivatives as Highly Potent Antagonists of Gastrin/Cholecystokinin-B Receptors. III
- Synthesis of Phenoxyacetic Acid Derivatives as Highly Potent Antagonists of Gastrin/Cholecystokinin-B Receptors. II
- Synthesis of Phenoxyacetic Acid Derivatives as Highly Potent Antagonists of Gastrin/Cholecystokinin-B Receptors
- Restorative Effect of Shosaikoto (Kampo Medicine) on Diminution of Nitric Oxide Synthesis in Murine Peritoneal Macrophages induced by Hyperocholesterolemia
- Anti-hyperlipidemic and Anti-atherosclerotic Actions of Shosaikoto (Kampo Medicine)
- SHOSAIKOTO (KAMPO MEDICINE) PROTECTS MACROPHAGE FUNCTION FROM SUPPRESSION BY HYPERCHOLESTEROLEMIA
- CLONING AND BACTERIAL EXPRESSION OF A GENE ENCODING RIBOSOME-INACTIVATING PROTEINS, KARASURIN-A AND KARASURIN-C, FROM TRICHOSANTHES KIRILOWII VAR. JAPONICA
- Studies on the Constituents of Calliandra anomala (KUNTH) MACBR. IV. Structure Analysis by HPLC Retention Time and FAB-MS Spectrum
- Basic Proteins Produced by Hairy Root Cultures of Trichosanthes Kirilowii var. japonica
- Studies on the Constituents of Calliandra anomala (KUNTH) MACBR. III. Structure Elucidation of Six Acylated Triterpenoidal Saponins
- The ST-Transformation Approach to Analytic Solutions of Quantum Systems. II : Transfer-Matrix and Pfaffian Methods : Condensed Matter and Statistical Physics
- Cytotoxic activities of alkaloids from Zephyranthes carinata