Hydroxy Monounsaturated Fatty Acids as Agonists for Peroxisome Proliferator-Activated Receptors
スポンサーリンク
概要
- 論文の詳細を見る
The physiological and pathological role of oxidized polyunsaturated fatty acids (PUFAs) has been extensively studied, whereas those of hydroxy monounsaturated fatty acids (MUFAs) are not well understood. This study demonstrated that 11-hydroxy-(9Z)-octadecenoic acid ((9Z)-11-HOE), which was isolated from adlay seeds (Coix lacryma-jobi L. var. ma-yuen STAF.), can activate peroxisome proliferator-activated receptor (PPAR)α, δ and γ in luciferase reporter assays more efficiently than (9Z)-octadecenoic acid (oleic acid), and to the same degree as linoleic acid. (9Z)-11-HOE increased the mRNA levels of UCP2 and CD36 in C2C12 myotubes and THP- 1 cells, respectively, and these effects were blocked by the PPARδ- and γ-specific antagonists GSK0660 and T0070907, respectively. Evaluation of the structure.activity relationship between hydroxy MUFAs and PPAR activation revealed that (9E)-11-HOE, the geometrical isomer of (9Z)-11-HOE, activated PPARs more potently than (9Z)-11-HOE, and that PPAR activation by hydroxyl MUFAs was not markedly influenced by the position of the hydroxy group or the double bond, although PPARδ seemed to possess ligand specificity different to that of PPARα or γ . Additionally, the finding that 11-hydroxy octadecanoic acid, the hydrogenated product of (9E)-11- HOE, was also capable of activating PPARs to a similar extent as (9E)-11-HOE indicates that the double bond in hydroxy MUFAs is not essential for PPAR activation. In conclusion, (9Z)-11-HOE derived from alday seeds and hydroxy MUFAs with a chain length of 16 or 18 acted as PPAR agonists. Hydroxylation of MUFAs may change these compounds from silent PPAR ligands to active PPAR agonists.
著者
-
Nagatsu A
Nagoya City Univ. Nagoya Jpn
-
INOUE Makoto
Laboratory of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Nagoya City University
-
TANABE Hiroki
Laboratory of Medicinal Resources, School of Pharmacy, Aichi Gakuin University
-
Yokoi Hiroshi
Laboratory Of Complex Systems Engineering Faculty Of Engineering Hokkaido University
-
MIZUKAMI Hajime
Laboratory of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Nagoya City University
-
Mizukami Hajime
Department Of Legal Medicine Asahikawa Medical College
-
Nagatsu Akito
Laboratory of Pharmacogonsy, Kinjo Gakuin University
-
Mizukami H
Dep. Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Nagoya City Univ.
-
Inoue Makoto
Laboratory Of Metabolic Biochemistry Faculty Of Agriculture Tottori University
-
Mizukami Hajime
Laboratory Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Nagoya City University
-
Inoue Makoto
Laboratory of Medicinal Resources, School of Pharmacy, Aichi Gakuin University
-
Nagatsu Akito
Laboratory of Pharmacognosy, Kinjo Gakuin University
関連論文
- P-25 メシマコブの低分子微量成分の研究(ポスター発表の部)
- Enzymatic preparation of 1-O-hydroxycinnamoyl-β-D-glucoses and their application to the study of 1-O-hydroxycinnamoyl-β-D-glucose-dependent acyltransferase in anthocyanin-producing cultured cells of Daucus carota and Glehnia littoralis
- Simultaneous analyses of hypoglycemic agents and C-peptide are essential in a homicide case with the combined dosing insulin and insulin-releasing drug
- The tissue distribution of lidocaine in acute death due to overdosing
- HPLC profiling of Phellinus linteus
- 105(P-62) Monensin二価誘導体のイオン輸送能とコンフォメーションに関する研究(ポスター発表の部)
- 73(P-63) メキシコ産ヒガンバナ科植物Zephyranthes carinataのアルカロイドとそのNMRスペクトルにおける特異な挙動(ポスター発表の部)
- 58(P-33) ポリエーテル抗生物質monensinおよび誘導体のNMRを用いた溶液中の立体配座推定へのアプローチ : Long range C-H結合定数を利用して(ポスター発表の部)
- 113(P48) イオノフォア抗生物質Monensinの化学修飾とイオン輸送活性(ポスター発表の部)
- Anti-atherosclerotic action of Saikokaryukotsuboreito against apoE-deficient mice
- Phenylethanoid and Iridoid Glycosides from Veronica persica
- New Phenylethanoid Glycosides from Veronica pectinata var. glandulosa and Their Free Radical Scavenging Activities
- Anti-inflammatory and Cytotoxic Activities of Five Veronica Species
- Forensic diagnosis of death from cold
- Catalase Contents in Cells Determine Sensitivity to the Apoptosis Inducer Gallic Acid
- Sesquiterpene Lactone Suppresses Vascular Smooth Muscle Cell Proliferation and Migration via Inhibition of Cell Cycle Progression(Pharmacognosy)
- DNA authentication of So-jutsu (Atractylodes lancea rhizome) and Byaku-jutsu (Atractylodes rhizome) obtained in the market based on the nucleotide sequence of the 18S-5.8S rDNA internal transcribed spacer region
- Serotonin Derivative, N-(p-Coumaroyl) serotonin, Isolated from Safflower (cathamus tinctorius L.) Oil Cake Augments the Proliferation of Normal Human and Mouse Fibroblasts in Synergy with Basic Fibroblast Growth Factor (bFGF) or Epidermal Growth Factor (E
- New Steroid and Matairesinol Glycosides from Safflower (Carthamus tinctorius L.) Oil Cake
- Suppressive Effect of Kanzo-bushi-to, a Kampo Medicine, on Collagen-Induced Arthritis(Pharmacognosy)
- Suppressive Effect of Dai-bofu-to on Collagen-Induced Arthritis(Pharmacognosy)
- Evaluation of Kampo medicines used to treat rheumatoid arthritis in collagen-induced arthritic and pX transgenic mice
- Antimetastatic Activity of Acteoside, a Phenylethanoid Glycoside
- Inhibition of Cell Cycle Progression through Specific Phase by Pancratistatin Derivatives
- Cytotoxic activities of alkaloids from Zephyranthes carinata
- Hydroxy Monounsaturated Fatty Acids as Agonists for Peroxisome Proliferator-Activated Receptors
- Phylogenetic Analysis of Atractylodes Plants Based on Chloroplast trnK Sequence
- Random Amplified Polymorphic DNA Analysis and Variation of Essential Oil Components of Atractylodes Plants
- Restriction Fragment Length Polymorphisms of rDNA and Variation of Essential Oil Composition in Atractylodes Plants
- Pharmacognostical Studies of Cistanchis Herba (IV) Phylogenetic Relationship of the Cistanche Plants Based on Plastid rps2 Gene and rpl16-rpl14 Intergenic Spacer Region Sequence
- Pharmacognostical Studies of Cistanchis Herba(III)Phylogenetic Relationship of the Cistanche Plants Based on Plastid rps2 Gene and rpl16-rpl14 Intergenic Spacer Sequences
- New Lignan Glycosides from Chinese Medicinal Plant, Sinopodophillum emodi
- Flavonoids from Sinopodophyllum emodi (Wall) Ying
- Two New Podophyllotoxin Glucosides from Sinopodophyllum emodi (WALL.) YING
- Inhibitory effect of oral intake of natural Phellinus linteus fruit body on growth and pulmonary metastasis of B16/BL6 melanoma
- P-174 Low molecular weight constituents in Phellinus linteus
- An Elicitor-Inducible NADP-Malic Enzyme in Lithospermum erythrorhizon Cultured Cells : cDNA Cloning and Characterization
- New Sesquiterpenes from Ferulaferulaeoides (STEUD.) KOROVIN. VI. Isolation and Identification of Three New Dihydrofuro[2,3-b]chromones
- Synthesis of 2-O-(4-Coumaroyl)-3-(4-hydroxyphenyl)lactic Acid, an Important Intermediate of Rosmarinic Acid Biosynthesis
- Cloning and Bacterial Expression of Karasurins, Ribosome-Inactivating Proteins (RIPs) from Trichosanthes Kirilowii var. Japonica
- Three New Glycosides from Sinopodophyllum emodi (WALL.) YING
- Purification and Characterization of UDP-Glucose : Curcumin Glucoside 1,6-Glucosyltransferase from Catharanthus roseus Cell Suspension Cultures
- DNA Authentication of Plantago Herb Based on Nucleotide Sequences of 18S-28S rRNA Internal Transcribed Spacer Region(Pharmacognosy)
- Systematic classification of alleles of the glycophorin A (MN blood group) gene
- Molecular evolution of alleles of the glycophorin A gene
- Selective Regulation of Multidrug Resistance Protein in Vascular Smooth Muscle Cells by the Isoquinoline Alkaloid Coptisine
- Sesquiterpenoid Derivatives from Ferula ferulioides. V
- Sesquiterpenoid Derivatives from Ferula ferulioides. IV
- Sequiterpenoid Derivatives from Ferula ferulioides. III
- Sesquiterpenoid Derivatives from Ferula ferulioides. II.
- Sesquiterpenoid Derivatives from Ferula ferulioides
- LONG-TERM ADMINISTRATION OF "SHO-SAIKO-TO" INCREASES CYTOCHROME P-450 mRNA LEVEL IN MOUSE LIVER
- Effect of Karasurin-A on Nitric Oxide Production by Murine Macrophages and Mitogenic Response of Murine Splenocytes in Vitro
- Peroxisome Proliferator-Activated Receptor γ Ligands Isolated from Adlay Seed(Coix lacryma-jobi L. var. ma-yuen STAPF)(Pharmacognosy)
- Phellifuropyranone A : A New Furopyranone Compound Isolated from Fruit Bodies of Wild Phellinus linteus
- ILVII-3 Kampo Medicines (Herbal Prescriptions in Japanese Traditional Medicine) as Molecular Library for Drug Development(Chemistry and Biochemistry Related to Biodiversity)
- RAPD Analysis of Ephedra Plants
- Studies on Chemical Modification of Monensin IX. Synthesis of 26-Substituted Monensins and Their Na^+Ion Transport Activity
- Identification of the Crude Drug Atractylodes Rhizome (Byaku-jutsu) and Atractylodes Lancea Rhizome (So-jutsu) Using Chloroplast TrnK Sequence as a Molecular Marker
- New Isoflavones and Flavanol from Iris potaninii
- On-line Learning Based Electromyogram to Forearm Motion Classifier with Motor Skill Evaluation
- Development of a morpho-functional machine : design of an amoeba-like reconfigureable robot
- Functional and Structural Characterization of a Flavonoid Glucoside 1,6-Glucosyltransferase from Catharanthus roseus
- CLONING AND BACTERIAL EXPRESSION OF A GENE ENCODING RIBOSOME-INACTIVATING PROTEINS, KARASURIN-A AND KARASURIN-C, FROM TRICHOSANTHES KIRILOWII VAR. JAPONICA
- Basic Proteins Produced by Hairy Root Cultures of Trichosanthes Kirilowii var. japonica
- Development of highly sensitive hantavirus genome detection methods and analysis of the viral replication
- Amino Acid Sequences and Ribosome-Inactivating Activities of Karasurin-B and Karasurin-C
- Induction and Partial Characterization of Antibacterial Proteins in the Hemolymph of the Silkworm, Bombyx mori(Biological Chemistry)
- pX Gene Causes Hypercholesterolemia in Hypercholesterolemia-Resistant BALB/c Mice(Miscellaneous)
- Pharmacognostical Studies of Cistanchis Herba (IV) Phylogenetic Relationship of the Cistanche Plants Based on Plastid rps2 Gene and rpl16-rpl14 Intergenic Spacer Region Sequence
- Geographical Variation in the Furanocoumarin and Polyacetylenic Compound Compositions of Wild Glehnia littoralis Plants
- Flavonoids from Sinopodophyllum emodi (Wall) Ying(Natural Medicine Note)
- RAPD Analysis of Ephedra Plants
- Cytotoxic activities of alkaloids from Zephyranthes carinata
- β-Cryptoxanthin Suppresses the Adipogenesis of 3T3-L1 Cells via RAR Activation
- A Naturally Occurring Rexinoid, Honokiol, Can Serve as a Regulator of Various Retinoid X Receptor Heterodimers
- qHNMR法を用いた生薬成分の定量分析