Botulinum Toxin C3 Inhibits Hyperalgesia in Mice With Partial Sciatic Nerve Injury
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概要
- 論文の詳細を見る
Mice with partial ligation of the sciatic nerve exhibited marked increase in the second phase nociceptive biting and licking behavior following intraplantar injection of formalin.The intrathecal pretreatment with botulinum toxin C3 dose−dependently attenuated the hyperalgesia in the second phase.These results suggest that a small G protein, Rho, and its downstream mechanisms are involved in the hyperalgesia following partial nerve injury.
- 社団法人 日本薬理学会の論文
- 2000-06-01
著者
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Ueda Hiroshi
Department Of Dermatology Fujita Health University School Of Medicine
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Inoue M
Department Of Ophthalmology Keio University School Of Medicine
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Inoue Makoto
Department Of Biological Chemistry Faculty Of Pharmaceutical Sciences Nagoya City University
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YE Xun
Department of Molecular Pharmacology and Neuroscience, Nagasaki University School of Pharmaceutical
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Ye Xun
Department Of Molecular Pharmacology And Neuroscience Nagasaki University School Of Pharmaceutical S
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Ueda Hiroshi
Department Of Anatomy School Of Medicine University Of Occupational And Environmental Health
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