PROTECTIVE EFFECTS OF JUZENTAIHOTO, DRIED DECOCTUM OF 10 CHINESE HERBS MIXTURE, UPON THE ADVERSE EFFECTS OF MITOMYCIN C IN MICE
スポンサーリンク
概要
- 論文の詳細を見る
In view of the reduction of side effects as well as the enhancement of anti-tumor activities of anticancer drugs, we have been interested in the combined use of Chinese medicines with them. In the present study we attempted to examine the effects of Chinese prescription, Juzentaihoto (JTX), combined with mitomycin C (MMC). JTX is consisted of Astragali radix, Chinnamomi cortex, Rehmanniae radix, Paeonia radix, Cnidii rhizoma, Atractylodis lanceae rhizoma, Angelicae radix, Ginseng radix, Hoelen and Glycyrrhizae radix. In BDF_1-mice which were implanted with P-338 leukemic cells, JTX prolonged significantly the average survival days of MMC-treated group. In tumor-free BDF_1-mice, JTX improved the leukopenia and the body weight loss which were caused by MMC. Additionally, JTX delayed the appearance of deaths by lethal dosis of MMC. These results indicate that JTX enhances the anti-tumor activity of MMC and lessens the adverse effects of it. JTX may be useful for patients undertaking MMC treatment.
- 公益社団法人日本薬学会の論文
著者
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HOSOYA EIKICHI
Tsumura Research Institute for Pharmacology
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Takeda Shigefumi
Tsumura Laboratory
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Ito Eiko
Tsumura Research Institute For Pharmacology
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Aburada Masaki
Tsumura Co. Ltd.
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NAKAMURA MOE
Tsumura Research Institute for Pharmacology
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