VOMITING INDUCTION BY IPECAC SYRUP IN DOGS AND FERRETS
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概要
- 論文の詳細を見る
The dog has been used as an experimental animal in emesis research. In this study, we analyzed the emetic effects of ipecac syrup using a smaller animal, the ferret, and compared its response to that of the dog. Dogs and ferrets were divided into 4 groups (n=4, each). Each group was given either 0.1, 0.25, 0.5, or 1.0 ml/kg of ipecac syrup, and the latency and numbers of retching and vomiting were recorded. Animals given an equal volume of saline served as controls. The numbers of vomiting and retching increased dose-dependently in both dogs and ferrets, and there was no difference in latency and numbers of vomiting between them. The numbers of retching were greater in ferrets than in dogs at ≧0.25 ml/kg. Taking these results into consideration, the ferret seems to be as useful as the dog in studies on emetic effects of ipecac syrup.
- 日本トキシコロジー学会の論文
- 1997-12-15
著者
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Takeda Shinya
R & D Center Calpis Co. Ltd.
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FUJII Yuichi
Tsumura & Co.
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TAKEDA Yasunori
Tsumura & Co.,
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YAMASHITA Mamoru
Department of Physics Engineering, Faculty of Engineering, Mie University
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Takeda Shigefumi
Tsumura Research Institute For Pharmacology
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Takeda Shigefumi
Tsumura Laboratory
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Takeda Shigefumi
Institute Of Clinical Medicine University Of Tsukuba
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Yamashita Masatomo
Department Of Emergency Medicine Institute Of Clinical Medicine University Of Tsukuba
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Yamashita Mamoru
Department Of Applied Physics Nagoya University
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Fujii Y
Tsumura & Co. Central Reserach Laboratories
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TANAKA Junsuke
Department of Emergency Medicine, Institute of Clinical Medicine, University of Tsukuba
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CHAGI Kyoji
Drug Safety Testing Center Co., Ltd.
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KURIHARA Takashi
Tsumura & Co.
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Chagi Kyoji
Drug Safety Testing Center Co. Ltd.
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Tanaka Junsuke
Department Of Emergency Medicine Institute Of Clinical Medicine University Of Tsukuba
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Takeda Yasunori
Tsumura & Co.
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Yamashita Mamoru
Department Of Applied Physics Faculty Of Engineering Nagoya University
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Kurihara Takashi
Tsumura & Co.
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Yamashita Mamoru
Department Of Applicad Physics Faculty Of Engineering Nagoya University
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