Structure and Synthesis of a New Monoterpenoidal Carboxamide from the Seeds of the Thai Medicinal Plant Acacia concinna
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概要
- 論文の詳細を見る
A new monoterpenoidal carboxamide, concinnamide (1), has been isolated from the seeds of a Thai medicinal plant, Acacia concinna DC. (Leguminosae). Its structure has been revised to (E)-2,6-dimethyl-6-hydroxy-2,7-octadienamide by detailed spectroscopic and synthetic studies, though it had been preliminarily assigned as a seven-membered lactam derivative by our previous work. (-)-Concinnamide, (-)-1,was synthesized from (-)-linalool (2) by stepwise oxidation, followed by amidation to confirm the structure. The inhibitory effects of 1 and related compounds on the arachidonate 5-lipoxygenase of RBL-1 cells are also described.
- 社団法人日本薬学会の論文
- 1997-01-15
著者
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Sekine Toshikazu
Faculty Of Engineering Gifu University
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Sekine Toshikazu
Faculty Of Pharmaceutical Sciences Chiba University
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IKEGAMI Fumio
Faculty of Pharmaceutical Sciences, Chiba University
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FUKASAWA Nobuaki
Faculty of Pharmaceutical Sciences, Chiba University
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SAITO Kazuki
Faculty of Pharmaceutical Sciences, Chiba University
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FUJII Yuichi
Tsumura & Co.
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MURAKOSHI Isamu
Faculty of Pharmaceutical Sciences, Chiba University
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Murakoshi I
Faculty Of Pharmaceutical Sciences Chiba University
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Murakoshi Isamu
Faculty Of Pharmaceutical Sciences Chiba University
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Fukasawa Nobuaki
Faculty Of Pharmaceutical Sciences Chiba University
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Ikegami Fumio
Faculty Of Pharmaceutical Sciences Chiba University
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Ikegami Fumio
Faculty Of Engineering Takushoku University
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Saito K
Graduate School Of Pharmaceutical Sciences Chiba University
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Saito Kazuki
Faculty Of Engineering Shizuoka University
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Saito K
Saitama Institute Of Public Health
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Fujii Yuichi
Tsumura & Co.
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Saito Kazuki
Faculty Of Pharmaceutical Sciences Laboratory Of Molecular Biology And Biotechnology Research Center
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SEKINE Toshikazu
Faculty Engineering Gifu University Japan
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