TJN-259 Improves Mesangial Lesions in Experimental Immunoglobulin A Nephropathy in ddY Mice
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概要
- 論文の詳細を見る
TJN-259 is a chemical substance based on the structural features of the botanically derived ingredient acteoside. This study was performed in order to elucidate the antinephritic effects of TJN-259 in experimental immunoglobulin A (IgA) nephropathy. In this study, 28-week-old ddY mice were used as a spontaneous model of IgA nephropathy. With regard to spontaneous IgA nephropathy, we investigated the effects of TJN-259 administered from 28 to 40 weeks. In addition, an accelerated model of IgA nephropathy was experimentally induced in ddY mice by oral administration of bovine serum albumin, followed by reticuloendothelial blocking by colloidal carbon injection and heminephrectomy. At 10 weeks after the 3rd carbon injection, we also examined the effects of TJN-259 on accelerated IgA nephropathy. To investigate the effects of TJN-259 on transforming growth factor (TGF)-β1 production in accelerated IgA nephropathy, kidneys were isolated and measured TGF-β1 by the enzyme-linked immunosorbent assay (ELISA) method. The administration of TJN-259 to mice with spontaneous IgA nephropathy decreased the incidence of mesangial expansion as well as the number of nuclei per glomerular cross-section in comparison with that of non-treated mice. In addition, TJN-259 treatment prevented the increase in the incidence of mesangial expansion, crescent formation, and segmental sclerosis in glomeruli in accelerated IgA nephropathy. TJN-259 also inhibited the increased immunostaining score of collagen type IV and TGF-β1 in glomeruli of accelerated IgA nephropathy. Treatment with TJN-259 inhibited the increases in renal total and mature TGF-β1 protein levels in accelerated type IgA nephropathy. TJN-259 failed to inhibit the increase in serum IgA levels in both models. These results suggest that TJN-259 was an effective treatment against IgA nephropathy in ddY mice, acting via the suppression of TGF-β1 production in glomeruli.
- Pharmaceutical Society of Japanの論文
著者
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TAKEDA Hiroshi
Department of Medical Information Science, Osaka University Graduate School of Medicine
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竹田 秀一
ツムラ研究本部
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HATTORI Tomohisa
Tsumura and Co., Pharmacology Research Department, R&D Division
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TAKEDA Shuichi
Tsumura and Co., Pharmacology Research Department, R&D Division
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Hattori Tomohisa
Tsumura & Co. Tsumura Res. Laboratories
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Sadakane Chiharu
Tsumura Research Laboratories, Tsumura & Co.
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Koseki Junichi
Tsumura Research Laboratories, Tsumura & Co.
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Hasegawa Yoshihiro
Tsumura Research Laboratories, Tsumura & Co.
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Shindo Shoichiro
Tsumura Research Laboratories, Tsumura & Co.
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竹田 秀一
Tsumura & Co. Tsumura Res. Laboratories
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Inagaki Yayoi
Tsumura Research Laboratories, Tsumura & Co.
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Takeda Hiroshi
Department Of Earth And Planetary Science The University Of Tokyo
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Takeda Shuichi
Department Of Drug Metabolism & Disposition Tsumura Research Institute Tsumura & Co.
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Sadakane Chiharu
Tsumura Research Laboratories Tsumura & Co.
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Hasegawa Yoshihiro
Tsumura Research Laboratories Tsumura & Co.
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Koseki Junichi
Tsumura Research Laboratories Tsumura & Co.
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Takeda Hiroshi
Division Of Pharmasciences Department Of Pathophysiology And Therapeutics Faculty Of Pharmaceutical
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Sadakane Chiharu
Tsumura Central Research Laboratory Tsumura Co.
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Shindo Shoichiro
Tsumura Research Laboratories Tsumura & Co.
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Takeda Hiroshi
Department Of Abdominal Surgery Tenri Hospital
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Takeda Shuichi
Tsumura & Co. Tsumura Research Laboratories
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Inagaki Yayoi
Tsumura Research Laboratories, Tsumura & Co.
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Hasegawa Yoshihiro
Tsumura & Co., Tsumura Research Laboratories
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Shindo Shoichiro
Tsumura & Co., Tsumura Research Laboratories
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Koseki Junichi
Tsumura Research Laboratories, Tsumura & Co.
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Takeda Shuichi
Tsumura Research Laboratories, Tsumura & Co.
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Hattori Tomohisa
Tsumura Research Laboratories, Tsumura & Co.
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Koseki Junichi
Tsumura & Co., Tsumura Research Laboratories
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Sadakane Chiharu
Tsumura & Co., Tsumura Research Laboratories
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