Eradication of Helicobacter pylori for primary gastric cancer and secondary gastric cancer after endoscopic mucosal resection.
スポンサーリンク
概要
- 論文の詳細を見る
Because most gastric cancers develop from a background of Helicobacter pylori-infected gastric mucosa, H. pylori plays an important role in gastric carcinogenesis. Therefore, eradication of H. pylori may inhibit the incidence of gastric cancers. In experimental studies, H. pylori eradication has proved to act as a prophylaxis against gastric cancer. However, the results of recent randomized controlled studies are absolutely contradictory. In Japan, mucosal gastric cancer is usually resected by endoscopic treatment. As only a small part of the gastric mucosa is resected, secondary gastric cancer after endoscopic resection of the primary gastric cancer often develops at another site in the stomach. A nonrandomized Japanese study involving 132 early gastric cancer patients reported that eradication of H. pylori after endoscopic resection tended to reduce the development of secondary gastric cancer. Also, a retrospective multicenter survey indicated that the incidence rate of secondary gastric cancer in H. pylori-eradicated patients was about one-third that among patients in the noneradication group. We conducted a large-scale multicenter randomized trial to confirm the effect of H. pylori eradication on secondary and residual gastric cancer after endoscopic resection. This study was begun in 2003 and is ongoing at present. Diagnosis of a new carcinoma at another site of the stomach is defined as the primary end point, and recurrence of tumors at the resection site as a secondary end point. A total of 542 subjects have been enrolled in the study. This study will have the statistical power to demonstrate whether H. pylori eradication decreases the incidence and recurrence of gastric cancer.
- 2007-01-01
著者
-
TAKEDA Hiroshi
Department of Medical Information Science, Osaka University Graduate School of Medicine
-
Hige Shuhei
Department Of Gastroenterology And Hematology Hokkaido University
-
Hige Shuhei
Department Of Gastroenterology And Hematology Hokkaido University Graduate School Of Medicine
-
Nakagawa Manabu
Division of Radiology, Sendai Kousei Hospital
-
Asaka Masahiro
Department Of Gastroenterology And Hematology Hokkaido University Graduate School Of Medicine
-
KATO MOTOSUGU
Division of Endoscopy, Hokkaido University Hospital
-
ONO SHOUKO
Division of Endoscopy, Hokkaido University Hospital
-
NAKAGAWA SOUICHI
Division of Endoscopy, Hokkaido University Hospital
-
SHIMIZU YUICHI
Division of Endoscopy, Hokkaido University Hospital
-
CHUMA MAKOTO
Department of Gastroenterology, Hokkaido University Graduate School of Medicine
-
KAWAKAMI HIROSHI
Department of Gastroenterology, Hokkaido University Graduate School of Medicine
-
KOMATSU YOSHITO
Department of Gastroenterology, Hokkaido University Graduate School of Medicine
-
Komatsu Yoshito
Department Of Gastroenterology Hokkaido University Graduate School Of Medicine
-
Kagaya Hidetoshi
Department Of Gastroenterology Hokkaido University Graduate School Of Medicine
-
Kagaya Hidetoshi
北海道大学 第3内科
-
Kato Mototsugu
Division Of Endoscopy Hokkaido University Medical Hospital
-
Takeda Hiroshi
Department Of Earth And Planetary Science The University Of Tokyo
-
Nakagawa Manabu
Division Of Radiology Sendai Kousei Hospital
-
Chuma Makoto
Department Of Gastroenterology And Hematology Hokkaido University
-
Nakagawa Souichi
Division Of Endoscopy Hokkaido University Hospital
-
Nakagawa Manabu
Division Of Endoscopy Hokkaido University Hospital
関連論文
- Impact of Diabetes Mellitus on Rehospitalization for Heart Failure Among Survivors of Acute Myocardial Infarction in the Percutaneous Coronary Intervention Era
- Up-Regulation of Cell Adhesion Molecule Genes in Human Endothelial Cells Stimulated by Lymphotoxin Alpha : DNA Microarray Analysis
- The influence of hepatitis B DNA level and antiviral therapy on recurrence after initial curative treatment in patients with hepatocellular carcinoma
- TJN-331 Improves Anti-glomerular Basement Membrane Nephritis by Inhibiting the Production of Intraglomerular Transforming Growth Factor-β1
- PJ-806 Assessment of Coronary Artery Stent by 320-Multidetector-Row Computed Tomography(PJ135,CT/MRI (Coronary/Vascular) 2 (I),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-736 Renal Dysfunction is a Predictor for In-hospital Mortality of Patients with Acute Aortic Dissection(PJ124,Peripheral Cirulation/Vascular Disease (Therapy) 4 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulatio
- PJ-622 320-row Area Detector Computed Tomography for Quantification of Severity in Patients with Aortic Valve Stenosis(PJ104,CT/MRI (Myocardium) 3 (I),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PE-418 Assessment of Myocardial Perfusion after Acute Myocardial Infarction by 320-Multidetector-Row Computed Tomography(PE070,CT/MRI (Myocardium) (I),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-035 320-slice Multidetector Computed Tomography Coronary Angiography in Real World(OJ06,CT/MRI (Coronary/Vascular) (I),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- OE-248 The Effect of Lumen Computed Tomography Density on Plaque Density : 320-slice Multidetector Computed Tomography Assessment(OE42,CT/MRI (Coronary/Vascular) 2 (I),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulat
- OE-159 Early Experience of 320-Multidetector-Row Computed Tomography to Evaluate Coronary Artery Flow Dynamics(OE27,CT/MRI (Coronary/Vascular) 1 (I),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- Eradication of Helicobacter pylori for primary gastric cancer and secondary gastric cancer after endoscopic mucosal resection.
- Graft-versus-tumor effect after reduced-intensity allogeneic hematopoietic stem cell transplantation in a patient with advanced colon cancer
- Antioxidative Effects of Choi-joki-to and its Ability to Inhibit the Progression of Atheroma in KHC Rabbits
- Safety of irinotecan and infusional fluorouracil/leucovorin (FOLFIRI) in Japan : a retrospective review of 48 patients with metastatic colorectal cancer
- Successful treatment of acute myelogenous leukemia with favorable cytogenetics by reduced-intensity stem cell transplantation
- Short-term and long-term outcome of endoluminal gastroplication for the treatment of GERD : the first multicenter trial in Japan
- CHANGE OF α-ACTININ IN REPERFUSED MYOCARDIUM
- Primary Paraganglioma of the Head of Pancreas : Contribution of Combinatorial Image Analyses to the Diagnosis of Disease
- ^C-Urea breath test, using a new compact nondispersive isotopeselective infrared spectrophotometer : comparison with mass spectrometry
- Comparison between a new ^C-urea breath test, using a film-coated tablet, and the conventional ^C-urea breath test for the detection of Helicobacter pylori infection
- Primary acinar cell carcinoma of the ampulla of Vater
- Chronic hepatitis C in patients co-infected with human immunodeficiency virus in Japan : a retrospective multicenter analysis
- INVESTIGATION OF LOW-DOSE ASPIRIN-INDUCED GASTRODUODENAL DAMAGE ACCORDING TO H. PYLORI INFECTION STATUS
- Thrombotic microangiopathy after treatment with bortezomib and dexamethasone in a patient with multiple myeloma
- Administration of micafungin as prophylactic antifungal therapy in patients undergoing allogeneic stem cell transplantation
- Acute-Onset Pancytopenia in a Postpartum Lactating Woman
- Donor-Type Myelodysplastic Syndrome with t(2;3) and Monosomy 7 after Allogeneic Peripheral Blood Stem Cell Transplantation and Liver Transplantation in a Patient with Severe-Type Aplastic Anemia
- EX VIVO CASE STUDY OF ENDOCYTOSCOPY IN SUPERFICIAL ESOPHAGEAL CANCER
- Hepatitis B virus genotype G is an extremely rare genotype in Japan
- Effects of NIP - 502 on Antigen - Induced Bronchial Responses and Allergic Reactions in Animal Models
- Studies on Anti-allergic Action of AH 21-132, a Novel Isozyme-Selective Phosphodiesterase Inhibitor in Airways
- Circadian Variation of the Onset of Acute Myocardial Infarction in the Osaka Area, 1998-1999 : Characterization of Morning and Nighttime Peaks
- Differential Impact of Smoking on Target Lesion Revascularization after Balloon Angioplasty and Stenting to Ischemic Heart Diseases
- Efficacy and safety of Micafungin in Febrile NeutropenicPatients Treated for Hematological Malignancies
- In vitro induction of resistance to metronidazole, and analysis of mutations in rdxA and frxA genes from Helicobacter pylori isolates
- Aleukemic leukemia cutis in a patient with Philadelphia chromosome-positive biphenotypic leukemia.
- Breast Conservation for Huge-sized Locally Advanced Breast Cancer: A Case Report
- Expression profiling in hepatocellular carcinoma with intrahepatic metastasis : identification of high-mobility group I(Y) protein as a molecular marker of hepatocellular carcinoma metastasis
- Pulmonary tumor embolism in a case of hepatocellular carcinoma.
- HCV non-structural protein 3 and HCV RNA genome in non-Hodgkin lymphoma and transition of the serum HCV RNA level : a retrospective analysis in one institution
- A Case of Non-Hodgkin's Lymphoma and Invasive Thymoma Treated with R-CHOP Therapy
- Successful Reduced-intensity Stem Cell Transplantation (RIST) for a Patient with Malignant Lymphoma and an Ileostomy
- Successful Micafungin (FK463) Treatment of Invasive Pulmonary Aspergillosis in a Patient with Acute Lymphoblastic Leukemia in a Phase II Study
- Rhabdomyolysis Caused by Distigmine Bromide
- Carcinoma In Situ of the Pancreas Associated with Localized Fibrosis : A Clue to Early Detection of Neoplastic Lesions Arising from Pancreatic Ducts
- Prevalence of Helicobacter Pylori Infection and Its Link to Coronary Risk Factors in Japanese Patients With Acute Myocardial Infarction
- Exfoliative Esophagitis Early After Autologous Peripheral Blood Stem Cell Transplantation
- Case Report of 14-Year Survival after Radiotherapy for Clinical T3 Esophageal Carcinoma, with Local Recurrence Finally Rescued by Surgery
- TJN-259 Improves Mesangial Lesions in Experimental Immunoglobulin A Nephropathy in ddY Mice
- Evaluation of the Observed Cisplatin Nephrotoxicity in Adult Cancer Inpatients : A Historical Cohort Study by Using Clinical Data Warehouse
- MAGNIFYING ENDOSCOPIC FINDINGS OF NON-EROSIVE REFLUX DISEASE
- THE RESULTS OF QUESTIONNAIRE ABOUT ENDOSCOPIC MUCOSAL RESECTION IN THE STOMACH
- Experimental petrology of ancient lunar mare basalt Asuka-881757: Spinel crystallization as a petrologic indicator
- Evaluation of upper abdominal symptoms using the Frequency Scale for the Symptoms of Gastroesophageal Reflux Disease in patients with laryngopharyngeal reflux symptoms
- Improvement of Long-standing Iron-deficiency Anemia in Adults after Eradication of Helicobacter pylori Infection
- Pathophysiological roles of macrophage migration inhibitory factor in gastrointestinal, hepatic, and pancreatic disorders
- Sensitive Assay for Quantification of Hepatitis B Virus Mutants by Use of a Minor Groove Binder Probe and Peptide Nucleic Acids
- Possible Acute Hemorrhagic Leukoencephalitis Manifesting as Intracerebral Hemorrhage on Computed Tomography : Case Report
- DRUG EFFECTS ON ELECTRICAL ACTIVITIES OF THE CANINE TRACHEAL CILIATED CELLS
- EFFECTS OF SOME DRUGS ON THE IMMUNE RESPONSE IN THE RESPIRATORY TRACT
- Influence of Itraconazole Co-administration and CYP2D6 Genotype on the Pharmacokinetics of the New Antipsychotic ARIPIPRAZOLE
- Decreased Motility of the Lower Esophageal Sphincter in a Rat Model of Gastroesophageal Reflux Disease May Be Mediated by Reductions of Serotonin and Acetylcholine Signaling
- ANALYSES OF ACTIVE SUBSTANCES DYNAMICS IN THE CENTRAL NORADRENERGIC, DOPAMINERGIC, SEROTONERGIC, CHOLINERGIC AND AMINO ACIDERGIC NERVOUS SYSTEMS BY HPLC-MULTIPLE COULOMETRIC ECD
- Identification of Rosmarinic Acid as a Novel Antidepressive Substance in the Leaves of Perilla frutescens Britton var.acuta Kudo (Perillae Herba)
- Modification of the Effects of Benzodiazepines on the Exploratory Behaviors of Mice on a Hole-Board by Diabetes
- Day/Night Variation of 5-Hydroxyindole Acetic Acid Concentration in Rat Cerebrospinal Fluid After Acute and Long-Term Administration of a Selective Serotonin Reuptake Inhibitor, Fluvoxamine
- Variation of Monoamines and Their Metabolite Contents in the Cerebrospinal Fluid of Conscious Rats
- Biliary deposition of Liesegang rings presenting as a polypoid mass in the liver : Previously unrecognized lesion
- A Prospective Analysis of the Factors Influencing Pancreaticojejunostomy Performed Using a Single Method, in 100 Consecutive Pancreaticoduodenectomies
- Malignant Thymoma with Direct Invasion into the Peritoneal Cavity : Report of a Case
- Anomalous Duplicated Cystic Duct as a Surgical Hazard:Report of a Case
- The Effect of Short-term Continuous Epidural Morphine on Postoperative Pain After Laparoscopic Cholecystectomy
- Abnormal Vaginal Bleeding from Endometrial Polyps in a Woman Receiving Tamoxifen Therapy for Breast Cancer: Report of a Case
- Solitary Cavernous Hemangioma of the Duodenum : Report of a Case
- Preventive Effect of Simultaneously Infused Lipid Emulsion Against Thrombophlebitis During Postoperative Peripheral Parenteral Nutrition
- Molecular basis for development of gastric cancer-in vivo and in vitro studies
- Helicobacter pylori infection and gastric cancer
- Regulation of dopamine uptake by basic fibroblast growth factor and epidermal growth factor in cultured rat astrocytes
- Expression and Functional Characterization of Choline Transporter in Human Keratinocytes
- Effect of TJN-331 on Anti-Thy1 Nephritis in Rats via Inhibition of Transforming Growth Factor-β1 Production
- Improvement of Long-standing Iron-deficiency Anemia in Adults after Eradication of Helicobacter pylori Infection
- Localized Lymphoplasmacytic Sclerosing Cholecystitis in a Patient with Autoimmune Pancreatitis
- Autoimmune Pancreatitis Associated with Hemorrhagic Pseudocysts: A Case Report and Literature Review
- Pancreatic Metastasis from Renal Cell Carcinoma with Intraportal Tumor Thrombus
- Prognostic significance of serum CA19-9 levels in resected pancreatic cancer
- Pancreatic endocrine tumors with intraductal growth into the main pancreatic duct and tumor thrombus within the portal vein: a case report and review of the literature.
- Primary cholesterol hepatolithiasis associated with cholangiocellular carcinoma: a case report and literature review.
- Needle knife sphincterotomy for an impacted ampullary stone with difficult selective biliary cannulation
- Endoscopic nasobiliary drainage is the most suitable preoperative biliary drainage method in the management of patients with hilar cholangiocarcinoma
- Helicobacter pylori infection and Gastric Cancer
- EUS-FNA for suspected malignant biliary strictures after negative endoscopic transpapillary brush cytology and forceps biopsy
- Preoperative biliary drainage for hilar cholangiocarcinoma : which stent should be selected?
- Coccoid formation as a mechanism of species-preservation in Helicobacter pylori : An ultrastructural study
- Eradication of Helicobacter pylori for primary gastric cancer and secondary gastric cancer after endoscopic mucosal resection.
- Lansoprazole for secondary prevention of gastric or duodenal ulcers associated with long-term non-steroidal anti-inflammatory drug (NSAID) therapy : results of a prospective, multicenter, double-blind, randomized, double-dummy, active-controlled trial
- Anemia and thrombocytosis induced by ribavirin monotherapy in patients with chronic hepatitis C
- Recommendation of lamivudine-to-entecavir switching treatment in chronic hepatitis B responders : Randomized controlled trial
- Combination of hepatitis B viral antigens and DNA for prediction of relapse after discontinuation of nucleos(t)ide analogs in patients with chronic hepatitis B
- Chronic hepatitis B in patients coinfected with human immunodeficiency virus in Japan : a retrospective multicenter analysis