Expression profiling in hepatocellular carcinoma with intrahepatic metastasis : identification of high-mobility group I(Y) protein as a molecular marker of hepatocellular carcinoma metastasis
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概要
- 論文の詳細を見る
Hepatocellular carcinoma (HCC) is one of the most common and aggressive human malignancies. Its high mortality rate is mainly a result of intra-hepatic metastases. To investigate the detailed genetic mechanisms in cancer metastasis, we compared the expression profiles of 20 HCCs with intrahepatic metastasis and 10 HCCs without intrahepatic metastasis using an oligonucleotide array. Of the approximately 12600 genes that were analyzed, we identified 34 genes whose expression levels were significantly correlated with intrahepatic metastasis (P < 0.05). Of these genes, we further investigated the expression of high-mobility group I(Y) [HMG-I(Y)] protein. Real-time quantitative reverse transcription polymerase chain reaction (RT-PCR) confirmed that HMG-I(Y) was up-regulated in HCC with intrahepatic metastasis, compared to its level in HCC without intrahepatic metastasis. Further immunohistochemical examination of HMG-I(Y) revealed a significant over-expression in HCC with intrahepatic metastasis, compared with that in HCC without intrahepatic metastasis (P < 0.05). These results indicate that the molecular signatures of HCC with intrahepatic metastasis and of HCC without intrahepatic metastasis are clearly different. HMG-I(Y) expression was associated with intrahepatic metastasis and may be a predictive marker of HCC intrahepatic metastasis.
- The Keio Journal of Medicineの論文
- 2004-06-01
著者
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HIROHASHI Setsuo
Pathology Division, National Cancer Center Research Institute and Hospital
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Asaka Masahiro
Department Of Gastroenterology And Hematology Hokkaido University Graduate School Of Medicine
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SAKAMOTO Michiie
Pathology Division, National Cancer Center Research Institute
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Hirohashi Setsuo
Pathology Division And National Cancer Center Research Institute
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CHUMA Makoto
Pathology Division and, National Cancer Center Research Institute
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SAEKI Norihisa
Genomics Division, National Cancer Center Research Institute
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YAMAMOTO Yoshiya
Pathology Division and, National Cancer Center Research Institute
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OHTA Tsutomu
Genomics Division, National Cancer Center Research Institute
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Chuma Makoto
Hokkaido Univ. Sapporo Jpn
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Chuma Makoto
Department Of Gastroenterology And Hematology Hokkaido University
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Sakamoto Michiie
Pathology Division And National Cancer Center Research Institute
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Saeki Norihisa
Genomics Division National Cancer Center Research Institute
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Ohta Tsutomu
Genomics Division National Cancer Center Research Institute
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Asaka M
Department Of Gastroenterology Hokkaido University Graduate School Of Medicine
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Asaka Masahiro
Department Of Cancer Preventive Medicine Graduate School Of Medicine Hokkaido University
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