Pathology and molecular mechanism of cancer invasion and metastasis
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概要
- 論文の詳細を見る
One of the most important issues in the field of cancer research is to understand and control the molecular mechanisms of cancer invasion and metastasis. While the pathobiology of human cancer metastasis is heterogeneous and complex, this seminar aims to outline the molecular and cellular mechanisms of cancer metastasis and discuss the application of our existing knowledge to clinical treatment. It has been shown that dysfunction/dysregulation of cell adhesion molecules and cell motility is critically involved in cancer invasion and metastasis. In liver cancer, it has been indicated that cell motility mediated by the Rho/Rho-associated kinase signaling pathway plays an important role in intrahepatic metastasis, and that Rho-associated kinase inhibitor could inhibit this metastasis. In addition to these cell biological approaches, new technologies that allow expression profiling of thousands of genes have been applied to surgical specimens, and several new metastasis-related molecules have been identified. Combination of careful histological observation and new technologies will greatly improve our understanding of cancer metastasis.
著者
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Sakamoto M
Department Of Pathology Keio University School Of Medicine
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SAKAMOTO Michiie
Pathology Division, National Cancer Center Research Institute
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Sakamoto Michiie
Pathology Division National Cancer Center Research Institute
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Sakamoto Michiie
Pathology Division And National Cancer Center Research Institute
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