Expression of Different Glycoforms of Membrane Mucin (MUC1) and Secretory Mucin (MUC2, MUC5AC and MUC6) in Pancreatic Neoplasms(Prof. K Watanabe Memorial Article)

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概要

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• Our previous studies of pancreatic tumors have demonstrated that invasive ductal carcinoma (IDC) usually showed expression of MUC1 (membrane bound type mucin) detected by monoclonal antibody DF3, whereas intraductal papillary-mucinous neoplasm (IPMN) showed no expression of MUC1. In the present study, we examined 50 IDCs, and 63 IPMNs which were morphologically classified into two histological subtypes, "dark cell type" (IPMN-D, 27 cases) and "clear cell type" (IPMN-C, 36 cases). Patients with either type of IPMN showed significantly better survival than those with IDC. To clarify the relationship of the expression patterns of mucins with their biological behavior, we examined the expression profiles of various glycoforms of membrane mucin (MUC1) and secretory mucin (MUC2, MUC5AC and MUC6) in the neoplasms using immuno-histochemistry. IDCs showed high expression of all the glycoforms of MUC1 (66%-98%). In contrast, IPMNs-D showed no or low expression of all the glycoforms of MUC1 (0%-4%), while IPMNs-C showed low expression of poorly glycosylated MUC1 (3%-6%), but expression of sialylated MUC1 (41%) and fully glycosylated MUC1 (69%). Expression of MUC2 was negative (0%) in IDC, high (96%) in IPMN-D and low (3%) in IPMN-C. MUC5AC was highly expressed in all types. MUC6 expression was higher in IPMNs-C (92%) than in IDCs (56%) and IPMNs-D (37%). In conclusion, the present study demonstrated that IDCs showed high expression of all the glycoforms of MUC1, and also that two types of IPMNs showed different expression patterns of glycosylated MUC1 as well as MUC2 and MUC6. These different expression patterns of mucins may be related with the malignancy potential of pancreatic neoplasms.

• 日本組織細胞化学会の論文

著者

• Sato Eiichi

  Division Of Cardiology Hoshi General Hospital

• 入村 達郎

  東京大薬学系研究科

• IRIMURA Tatsuro

  Laboratory of Cancer Biology and Molecular Immunology, Graduate School of Pharmaceutical Sciences, T

• Goto Masamichi

  Natl. Sanatorium Hoshizuka-Keiaien

• IMAI Kohzoh

  Sapporo Medical University

• Fukushima Noriyoshi

  Pathology Division National Cancer Center Research Institute

• IMAI Kohzoh

  Department of Internal Medicine, Sapporo Medical College

• Takao S

  Frontier Science Research Center Kagoshima University

• Takao Sonshin

  鹿児島大学 医歯学総合研究科腫瘍制御学･消化器外科学

• Takao Sonshin

  Laboratory For Bioengineering & Transplantation Research Center For Life Science Resources Kagos

• Takao Sonshin

  鹿児島大学 医歯総研究病理学第2

• Imai Kohzoh

  Department Of Internal Medicine Sapporo Medical College

• 佐藤 英一

  宇宙科学研究所

• Imai Kohzoh

  Department Of Internal Medicine (section 1) Sapporo Medical University School Of Medicine

• Imai Kohzoh

  Deparment Of Internal Medicine Sapporo Medical College

• Takao Sonshin

  Department Of Surgical Oncology Digestive Surgery Graduate School Of Medicine Kagoshima University

• Takao Sonshin

  First Department Of Surgery Kagoshima University School Of Medicine

• Nakamura A

  Shinshu Univ. School Of Medicine

• Goto Masamichi

  Division Of Research And Examination National Leprosarium Hoshizuka-keiaien

• SAKAMOTO Michiie

  Pathology Division, National Cancer Center Research Institute

• Miwa Atsuo

  Toyama Prefectural Central Hospital

• Horinouchi Michiko

  Division of Human Pathology, Department of Oncology, Kagoshima University, Graduate School of Medica

• Nagata Kohji

  Division of Human Pathology, Department of Oncology, Kagoshima University, Graduate School of Medica

• Nakamura Akiko

  Department of Surgery, Kagoshima Medical Association Hospital

• Takao Sonshin

  Division of Surgery, Department of Oncology, Kagoshima University, Graduate School of Medical and De

• Yonezawa Suguru

  Division of Human Pathology, Department of Oncology, Kagoshima University, Graduate School of Medica

• Tsuyama Shinichiro

  Second Department Of Anatomy Faculty Of Medicine Kagoshima University

• Tsuyama Shinichiro

  Department Of Anatomy Kagoshima University Faculty Of Medicine

• Ikeda Tatsuru

  The Department Of Clinical Pathology Sapporo Medical University

• Yonezawa S

  Dept. Hum. Pathol. Grad. Sch. Med. Dent. Sci. Kagoshima Univ.

• Horinouchi Michiko

  Dept. Hum. Pathol. Grad. Sch. Med. Dent. Sci. Kagoshima Univ.

• Irimura Tatsuro

  Laboratory Of Cancer Biology And Molecular Immunology ; Graduate School Of Pharmaceutical Sciences T

• Irimura Tatsuro

  Department Of Cancer Biology And Molecular Immunology Faculty Of Pharmaceutical Sciences University

• Nagata Koji

  Department Of Human Pathology Field Of Oncology Kagoshima University Graduate School Of Medical And

• Irimura T

  Univ. Tokyo Tokyo Jpn

• Tsuyama Shinichiro

  Department Of Structural Cell Biology Kagoshima University Graduate School Of Medical And Dental Sci

• Tsuyama Shinichiro

  Departments Of Structural Cell Biology Kagoshima University Graduate School Of Medical And Dental Sc

• Sato Eiichi

  岩手医科大学共通教育センター物理学科

• 佐藤 英一

  宇宙航空研究開発機構 宇宙科研

• Sakamoto M

  Pathology Division National Cancer Center Research Institute

• Sakamoto Michiie

  Pathology Division And National Cancer Center Research Institute

• Nakamura A

  Iwate Univ. Morioka Jpn

• Goto Masamichi

  Department Of Human Pathology Field Of Oncology Kagoshima University Graduate School Of Medical And

• Goto Masamichi

  Second Department Of Pathology Faculty Of Medicine Kagoshima University

• Nagata Koji

  Second Department Of Pathology Kagoshima University Scool Of Medicine

• Nakamura Akiko

  Department Of Bioscience And Technology Faculty Of Agriculture Iwate University

• Tsuyama S.

  Dept.anat. Fac.med. Kagoshima Univ.

• Tsuyama Shinichiro

  Department Of Structural Cell Biology Kagoshima University Graduate School Of Medical And Dental Sciences

• Takao Sonshin

  Division Of Surgery Department Of Oncology Kagoshima University Graduate School Of Medical And Dental Sciences

• NAKAMURA Akiko

  Department of Bacteriology, National Institute of Health

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