Poly(ADP-ribose) polymerase-1 gene in human tumor cell lines: Its expression and structural alteration

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概要

• 論文の詳細を見る

• Poly(ADP-ribose) polymerase-1 (Parp-1) is involved in DNA repair and cell-death induction after DNA damage. Parp-1-/- mice show higher susceptibility to the carcinogenic effects of nitrosamine and azoxymethane. To elucidate the role of alterations of the PARP-1 gene in human carcinogenesis, we examined the expression level of PARP-1 gene in various human tumor cell lines. The presence of gross rearrangement of PARP-1 gene in these cell lines was also examined by Southern blot hybridization analysis. The expression levels of PARP-1 gene in several cell lines, including T-cell leukemia cell lines (Molt-4 and CCRF-CEM), colon cancer cell line (WiDr), and gastric cancer cell lines (KatoIII, OKAJIMA, and MKN45) was substantially lower than in other cancer cell lines. Among the 85 analyzed cell lines, structural alteration of PARP-1 gene was detected in a gastric cancer cell line, MKN28. A low level of PARP-1 expression in human cancer could potentially influence cancer cell growth, differentiation and cancer development by affecting genomic instability, as well as the response of tumors to chemo- and radiotherapy. (Contributed by Takashi SUGIMURA, M.J.A., Feb. 12, 2004)

• 日本学士院の論文

著者

• KOHNO Takashi

  Biology Division, National Cancer Center Research Institute

• YOKOTA Jun

  Biology Division, National Cancer Center Research Institute

• NAKAGAMA Hitoshi

  Biochemistry Division, National Cancer Center Research Institute

• HIROHASHI Setsuo

  Pathology Division, National Cancer Center Research Institute and Hospital

• Nakagama Hitoshi

  Biochemistry Division National Cancer Center Research Institute

• Mori M

  Department Of Oral-maxillofacial Surgery Asahi University School Of Dentistry:medicaraise Corporatio

• SUGIMURA Takashi

  Biochemistry Division, National Cancer Center Research Institute

• NOZAKI Tadashige

  Biochemistry Division, National Cancer Center Research Institute

• MASUTANI Mitsuko

  Biochemistry Division, National Cancer Center Research Institute

• Nozaki T

  National Cancer Center Res. Inst. Tokyo Jpn

• Gotoh Masahiro

  Pathology Division National Cancer Center Research Institute

• Mori M

  Department Of Oral Surgery Gifu College Of Dentistry

• Kohno Takashi

  Biology Division National Cancer Center Research Institute

• Muto Masahiro

  Radiat. Hazards Res. G. Nirs

• SASAKI Hiroki

  Genetics Division, National Cancer Center Research Institute

• Hirohashi Setsuo

  Pathology Division And National Cancer Center Research Institute

• Noda T

  National Cancer Center Res. Inst. Tokyo Jpn

• Sasaki Hiroki

  Genetics Division National Cancer Center Research Institute

• Masutani Mitsuko

  Biochemistry Division National Cancer Center Research Institute

• Mori Masahiko

  Radiation Hazards Research Group National Institute Of Radiological Sciences

• YAMADA Tesshi

  Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute

• SHIMIZU Kimiko

  Molecular Oncology Division, National Cancer Center Research Institute

• SHIRAISHI Masahiko

  DNA Methylation and Genome Function Project, National Cancer Center Research Institute

• Noda T

  National Cancer Center Hospital Tokyo

• Masutani M

  National Cancer Cent. Res. Inst. Tokyo Jpn

• Muto Masahiro

  Department Of Oral Pathology Osaka Dental University

• Suzuki H

  Department Of Hepatology Toranomon Hospital

• Yokota Jun

  Biology Division National Cancer Center Research Institute

• Sugimura Takashi

  Biochemistry Division National Cancer Center

• Mori Masahiko

  Div. Radiobiology And Biodosimetory

• Hirohashi Setsuo

  Pathology Division, National Cancer Center Research Institute

• GOTOH Masahiro

  Pathology Division, National Cancer Center Research Institute

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