Phylogenic distribution of poly(ADP-ribose) glycohydrolase and poly(ADP-ribose)-digesting phosphodiesterase
スポンサーリンク
概要
- 論文の詳細を見る
Most of eukaryotes, except for Saccharomyces cerevisiae, possess poly(ADP-ribose) polymerase (PARP, EC 2.4.2.30) activity. Poly(ADP-ribose) is described to be mainly degraded by poly(ADP- ribose) glycohydrolase (PARG) and also by phosphodiesterase I (PDEase, EC 3.1.4.1). To understand the function and metabolism of poly(ADP-ribose), the distribution of poly(ADP-ribose) degradation activity in various kinds of species was investigated. Poly(ADP-ribose) degradation activity was detected in extracts from various kinds of eukaryotes including Rattus norvegicus, Sarcophaga peregrina, Caenorhabditis elegans, Dictyostelium discoideurn, Tetrahymena thermophila, Tetrahymena pyrifornis, and Neurospora crassa. However, poly(ADP-ribose) degradation activity was not observed in Schizosaccharomyces pombe, and prokaryotes, namely Escherichia coli and Halobacterium volcanii. The main degradation products of [32P]poly(ADP-ribose), which were detected by the radioactivity, were ADP-ribose, phosphoribosyl-AMP and 5-AMP at different ratios in each species. This suggests that PARG and PDEases are involved in the degradation of poly(ADP-ribose) at the initial step. Since poly(ADP-ribose) degradation due to PARG activity and PDEase activity, and poly(ADP-ribose) formation due to PARP activity were not detectable in Schizosaccharomyces pombe, Escherichia coli and Halobacterium volcanii, the presence of PARG as well as PDEase well correlates with that of PARP in various kinds of species.
- 日本学士院の論文
著者
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WAKABAYASHI Keiji
Cancer Prevention Division, National Cancer Center Research Institute
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NAKAGAMA Hitoshi
Biochemistry Division, National Cancer Center Research Institute
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Nakagama Hitoshi
Biochemistry Division National Cancer Center Research Institute
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Mori M
Department Of Oral-maxillofacial Surgery Asahi University School Of Dentistry:medicaraise Corporatio
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SUGIMURA Takashi
Biochemistry Division, National Cancer Center Research Institute
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NOZAKI Tadashige
Biochemistry Division, National Cancer Center Research Institute
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MASUTANI Mitsuko
Biochemistry Division, National Cancer Center Research Institute
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Wakabayashi Keiji
Cancer Prevention Basic Research Project National Cancer Center Research Institute
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SHIMOKAWA Takashi
Biochemistry Division, National Cancer Center Research Institute
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NAGASAWA Shingo
Biochemistry Division, National Cancer Center Research Institute
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Mori M
Department Of Oral And Maxillofacial Surgery School Of Dentistry Asahi University
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Mori M
Department Of Oral Surgery Gifu College Of Dentistry
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Muto Masahiro
Radiat. Hazards Res. G. Nirs
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Masutani Mitsuko
Biochemistry Division National Cancer Center Research Institute
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Mori Masahiko
Radiation Hazards Research Group National Institute Of Radiological Sciences
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Masutani M
National Cancer Cent. Res. Inst. Tokyo Jpn
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Muto Masahiro
Department Of Oral Pathology Osaka Dental University
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Shimokawa Takashi
Biochemistry Division National Cancer Center Research Institute
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Nagasawa S
Res. And Dev. Yanaihara Inst. Inc. Shizuoka Jpn
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Tamai Susumu
Cancer Prevention Division National Cancer Center Research Institute
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Sugimura Takashi
Biochemistry Division National Cancer Center
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Sasaki Toru
Tokushima Research Center Taiho Pharmaceutical Co. Ltd.
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Mori Masahiko
Div. Radiobiology And Biodosimetory
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