Detection of 3,3'-Dichlorobenzidine in Water from the Waka River in Wakayama, Japan
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概要
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In a previous study, we found that water concentrate from the Waka River, which flows through an industrial area in Wakayama, Japan, showed significant mutagenicity in Salmonella typhimurium YG1024 without a mammalian metabolic system (S9 mix), and 4-amino-3,3'-dichloro-5,4'-dinitrobiphenyl (ADDB) was identified as a major direct-acting mutagenic constituent in the water concentrate. ADDB induced 428,000 revertants/μg in YG1024 without S9 mix, and this activity was 48 times as high as that with S9 mix. In this study, to clarify whether other mutagenic contaminants were present in the river, water concentrates were collected at three sites along the Waka River and examined for mutagenicity by the Ames test using YG1024 and YG1029 with and without S9 mix. All water concentrates showed potent mutagenicity in YG1024 with and/or without S9 mix. ADDB was detected in water concentrate that was extremely mutagenic without S9 mix. An indirect-acting mutagen, which accounted for more than 30% of the total mutagenicity of the water concentrates in YG1024 with S9 mix, was isolated from two extremely mutagenic water concentrates by HPLC separation. On the basis of spectral data and co-chromatography using authentic chemicals, this mutagen was identified as 3,3'-dichlorobenzidine (DCB). DCB showed strong mutagenicity in YG1024 with S9 mix, inducing 5,186 revertants/μg. DCB was detected in water concentrates collected on the other three sampling dates in the range from 15.8 to 28.5μg/g of blue rayon. These results suggest that Waka River water might be continually contaminated with mutagens, and DCB was thought to be the major mutagenic constituent of the river water.
- 日本環境変異原学会の論文
- 2006-11-30
著者
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Watanabe Tetsushi
Department of Public Health, Kyoto Pharmaceutical University
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Hirayama Teruhisa
Department of Public Health, Kyoto Pharmaceutical University
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WAKABAYASHI Keiji
Cancer Prevention Division, National Cancer Center Research Institute
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Wakabayashi Keiji
Cancer Prevention Basic Research Project National Cancer Center Research Institute
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Hasei Tomohiro
京都薬科大学 公衆衛生学
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HIRAYAMA TERUHISA
Kyoto Pharmaceutical University
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Hasei Tomohiro
Department of Public Health, Kyoto Pharmaceutical University
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Ohe Takeshi
Department of Food Nutrition, Kyoto Women's University
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Ohe Takeshi
Department Of Food And Nutrition Kyoto Women's University
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Watanabe Tetsushi
Department Of Correlative Study In Physics And Chemisty Graduate School Of Integrated Basic Sciences
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Hirayama Teruhisa
Department Of Orthopaedic Surgery Asahikawa Medical College
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Hirayama Teruhisa
Kyoto College Of Pharmacy
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