Mutagenicity of Surface Soils in Urban Areas of Aichi Prefecture, Japan, and Bangkok, Thailand
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概要
- 論文の詳細を見る
To clarify the contamination levels of surface soil with mutagens in urban areas of Aichi prefecture, Japan, and Bangkok, Thailand, 60 and 67 surface soil samples were collected in Aichi and Bangkok, respectively, and mutagenicities of the organic extracts from these soil samples were examined in the Ames assay using Salmonella typhimurium (S. typhimurium) TA98 and TA100 with and without a mammalian metabolic system (S9 mix). Most of the soil samples collected in both areas showed mutagenicity in TA98 with and without S9 mix and in TA100 with S9 mix. Thirteen (22%) soil samples collected in Aichi showed high mutagenicity (more than 1000 revertants/g of soil) in TA98 with and/or without S9 mix, and six soil samples induced more than 4000 revertants/g of soil in TA98. Mutagenic potencies of most of the soil samples from Bangkok were moderate (100-500 revertants/g of soil) or low (less than 100 revertants/g of soil) in both strains with and without S9 mix, and only one sample induced more than 1000 revertants/g of soil in both strains. In the characterization of mutagens, organic extracts of two and one soil samples from Aichi and Bangkok, respectively, were separated on an octadecylsilyl (ODS) column for HPLC, and mutagenicities of the resulting fractions were examined using S. typhimurium YG1024 without S9 mix. For the two soil samples from Aichi, retention times of the distinct mutagenic fractions were similar at 40-74min, and especially high mutagenicities were detected in three fractions corresponding to dinitropyrene isomers. In contrast, distinct mutagenicities were detected at retention times of 6-29min for the sample from Bangkok, and marked mutagenicity was found in the fraction corresponding to another nitroarene. These results indicate that surface soils in urban areas in Aichi and Bangkok are commonly contaminated with mutagens, but major mutagenic constituents in the surface soils are different.
- 公益社団法人日本薬学会の論文
- 2005-12-01
著者
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Watanabe Tetsushi
Department of Public Health, Kyoto Pharmaceutical University
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Hirayama Teruhisa
Department of Public Health, Kyoto Pharmaceutical University
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WAKABAYASHI Keiji
Cancer Prevention Division, National Cancer Center Research Institute
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Wakabayashi Keiji
Cancer Prevention Basic Research Project National Cancer Center Research Institute
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Hasei Tomohiro
京都薬科大学 公衆衛生学
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Asanoma Masaharu
Nagoya City Public Health Research Institute
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HIRAYAMA TERUHISA
Kyoto Pharmaceutical University
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Hasei Tomohiro
Department of Public Health, Kyoto Pharmaceutical University
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Kusamran Wannee
Biochemistry and Chemical Carcinogenesis Section, Research Division, National Cancer Institute
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Tepsuwan Anong
Biochemistry and Chemical Carcinogenesis Section, Research Division, National Cancer Institute
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Tantasri Nopsarun
Biochemistry and Chemical Carcinogenesis Section, Research Division, National Cancer Institute
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Meesiripan Nuntana
Biochemistry and Chemical Carcinogenesis Section, Research Division, National Cancer Institute
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Murahashi Tsuyoshi
Department of Public Health, Kyoto Pharmaceutical University
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Tepsuwan Anong
Biochemistry And Chemical Carcinogenesis Section Research Division National Cancer Institute
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Watanabe Tetsushi
Department Of Correlative Study In Physics And Chemisty Graduate School Of Integrated Basic Sciences
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Hirayama Teruhisa
Department Of Orthopaedic Surgery Asahikawa Medical College
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Kusamran Wannee
Biochemistry And Chemical Carcinogenesis Section Research Division National Cancer Institute
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Tantasri Nopsarun
Biochemistry And Chemical Carcinogenesis Section Research Division National Cancer Institute
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Murahashi Tsuyoshi
Kyoto Pharmaceutical University:(present Office)nihon Pharmaceutical University
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Meesiripan Nuntana
Biochemistry And Chemical Carcinogenesis Section Research Division National Cancer Institute
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Hirayama Teruhisa
Kyoto College Of Pharmacy
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