A note on artificial induction of mutation upon testing 7,12-dimethylbenz[a]anthracene mutagenicity under fluorescent light in the absence of microsomal enzymes

概要

論文の詳細を見る
When mutagenicity assay was done under fluorescent lamps commonly used for room lighting, 7,12-dimethylbenz[a]anthracene (DMBA) showed mutagenicity without any enzymatic activation. The light between wavelength of 370 and 450 nm is responsible for the photoactivation of DMBA, which is corresponding to the absorption peak of DMBA. The formation of the direct-acting mutagen was inhibited by addition of cofactor for S9mix. These findings have relevance to the routine testing of chemicals for mutagenic activity.
日本環境変異原学会の論文
2001-10-20