Potent Mutagenic Potential of 4-Methylquinoline : Metabolic and Mechanistic Considerations
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概要
- 論文の詳細を見る
4-Methylquinoline (4-MeQ) showed an extraordinarily potent mutagenicity when compared to quinoline and isomeric methylquinolines. The major metabolite of 4-MeQ was 4-hydroxymethylquinoline, which was not mutagenic under the assay condition employed. Deuteration of the methyl group of 4-MeQ resulted in a decrease in the amount of the hydroxymethyl metabolite and an increase in mutagenicity, indicating that hydroxylation of the substitutent methyl group is a detoxication process. A 3-chloro derivative of 4-MeQ was proven to be non-mutagenic. 4-Ethylquinoline, as well as 4-hydroxymethylquinoline, was much less mutagenic than 4-MeQ. Taking account of the structure-mutagenicity relationship, a possible mechanism is proposed for the potent mutagenic potential of 4-MeQ.
- 公益社団法人日本薬学会の論文
- 1996-04-15
著者
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SAEKI Ken-ichi
Faculty of Pharmaceutical Sciences, Nagoya City University
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Kawazoe Y
Nagoya City Univ. Nagoya Jpn
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Saeki Ken-ichi
Faculty Of Engineering University Of Fukui
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TAKAHASHI Kazuhiko
Faculty of Pharmaceutical Sciences, Nagoya City University
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KAWAZOE Yutala
Faculty of Pharmaceutical Sciences, Nagoya City University
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Takahashi K
Teikyo Univ. Kanagawa Jpn
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Kawazoe Yutala
Faculty Of Pharmaceutical Sciences Nagoya City University
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Takahashi Kazuhiko
Faculty Of Pharmaceutical Sciences Nagoya City University
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Takahashi Kazuhiko
Faculty Of Pharmaceutical Sciences Hokkaido University
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