Enhanced Cytotoxicity of Alkyl Viologens and N, N'-Diamino Analogs toward Cultured Murine Leukemia L1210 Cells under Vortex-Stirring with a High Molecular Weight Polyacrylic Acid

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概要

• 論文の詳細を見る

• Alkyl viologens showed cytotoxicity when incubated with cultured murine leukemia L1210 cells for 48 h, whereas they were not cytotoxic when briefly incubated for 10 min. Under the permeabilizing conditions achieved by vortex-stirring with a high molecular weight polyacrylic acid (A-119), appreciable cytotoxicity was shown even after a 10-min exposure to any of the alkyl and amino viologens examined. Acetylamino viologen showed no cytotoxicity regardless of the presence or absence of A-119. This permeabilizing procedure was demonstrated to be applicable to internalize water-soluble positively charged viologen molecules into the cell.

• 公益社団法人日本薬学会の論文
• 1997-02-15

著者

• KAWAZOE Yutaka

  Faculty of Pharmaceutical Sciences, Nagoya City University

• Kawazoe Yutaka

  Faculty Of Pharmaceutical Science University Of Tokyo

• Kawazoe Y

  Nagoya City Univ. Nagoya Jpn

• Shimizu Noriko

  Kyoritsu University Of Pharmacy

• Wu W

  Department Of Chemistry University Of Missouri-rolla

• Wu W

  Changchun Inst. Applied Chemistry Chinese Acad. Sci. Changchun Chn

• Kohda Kohfuku

  Faculty Of Pharmaceutical Sciences Nagoya City University

• Kohda Kohfuku

  Faculty Of Pharmaceutical Sciences Nagoya City Uniersity

• Kohara Arihiro

  Faculty Of Pharmaceutical Sciences Nagoya City University

• SHIMIZU Naoaki

  Faculty of Pharmaceutical Sciences, Nagoya City University

• WU Wei

  Faculty of Pharmaceutucal Sciences, Kyushu University

• SUZUKI Takayoshi

  (Present address)National Institute of Hygienic Science

• Shimizu Naoaki

  Faculty Of Pharmaceutical Sciences Nagoya City University

• Wu Wei

  Faculty Of Pharmaceutical Sciences Nagoya City University

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