Mechanism of Formation of N^2-Benzylguanine in the Reaction of 2-Amino-6-chloropurine with Sodium Benzyl Oxide, and Benzylation of Nucleic Acid Bases

スポンサーリンク

概要

• 論文の詳細を見る

• The mechanism of formation of N^2-benzylguanine in the reaction of 2-amino-6-chloropurine with a large excess (12-13 molar eq) of sodium benzyl oxide in benzyl alcohol at 130℃ was studied, N^2,O^6-Dibenzylguanine, a reaction intermediate, was isolated and a possible mechanism for its formation is discussed. Furthermore, using this sodium benzyl oxide system, benzylation at the amino group of nucleic acid bases was facilitated.

• 公益社団法人日本薬学会の論文
• 1996-07-15

著者

• Hitomi Kenichi

  Faculty Of Pharmaceutical Sciences Nagoya City University

• Koyama Ken-ichi

  Faculty Of Pharmaceutical Sciences Nagoya City University

• Kohda Kohfuku

  Faculty Of Pharmaceutical Sciences Nagoya City Uniersity

• TERASHIMA Isamu

  Faculty of Pharmaceutical Sciences, Nagoya City University

• Terashima I

  Faculty Of Pharmaceutical Sciences Nagoya City University

• Terashima Isamu

  Faculty Of Pharmaceutical Sciences Nagoya City University

関連論文

• Enhanced Cytotoxicity of Some Triterpenes toward Leukemia L1210 Cells Cultured in Low pH media : Possibility of a New Mode of Cell Killing
• Isolation and characterization of Xenopus (6-4)photolyase.
• Isolation and characterization of Human photolyase homolog.
• Enhanced Cytotoxicity of Alkyl Viologens and N, N'-Diamino Analogs toward Cultured Murine Leukemia L1210 Cells under Vortex-Stirring with a High Molecular Weight Polyacrylic Acid
• Synergetic Cytotoxicity of Bleomycin and Polyhydric Alcohols : DNA Strand Breakage Evaluated by "Comet Assay"
• Mechanism of Formation of N^2-Benzylguanine in the Reaction of 2-Amino-6-chloropurine with Sodium Benzyl Oxide, and Benzylation of Nucleic Acid Bases
• Cytotoxicity of fluoroethylating Agents Is Potentiated by O^6-Benzylguanine

スポンサーリンク