Dual Stimulatory and Inhibitory Effects of Fluorine-Substitution on Mutagenicity : An Extension of the Enamine Epoxide Theory for Axtivation of the Quinoline Nucleus
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概要
- 論文の詳細を見る
Nineteen mono- and di-fluorinated derivatives of quinoline, 1,7-phenanthroline, 1,10-phenanthroline, benzo-[h]quinoline, and benzo[f]quinoline were subjected to analysis of their structure-mutagenicity relationships. For this purpose, six new fluorinated derivatives were synthesized. The results support that the enamine epoxide structure of the pyridine moiety, as well as the bay-region epoxide structure, is responsible for mutagenicity. Formation of K-region epoxides might involve a detoxification process rather than mutagenic activation.
- 公益社団法人日本薬学会の論文
- 1997-06-15
著者
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SAEKI Ken-ichi
Faculty of Pharmaceutical Sciences, Nagoya City University
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Kawazoe Yutaka
Faculty Of Pharmaceutical Science University Of Tokyo
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Hakura Atsushi
Department Of Drug Safety Research Eisai Co. Ltd.
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KAWAI HIROSHI
Faculty of Agriculture, Okayama University
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Saeki Ken-ichi
Faculty Of Engineering University Of Fukui
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