Fluorinated Benzo[h]quinolines and Benzo[f]quinolines

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概要

• 論文の詳細を見る

• Thirteen kinds of fluorinated derivatives of benzo[h]quinoline and benzo[f]quinoline were synthesized by means of the Schiemann reaction or Skraup reaction, or by an electrolytic method. The synthesized derivatives carry one or two fluorine atoms at the bay-region, the K-region, and/or on the pyridine moiety of the molecules. These compounds can be used as models to examine the effect upon genotoxicity of fluorine substitution at appropriate sites on aromatic rings. Physicochemical and spectroscopic data of the fluorinated derivatives are given.

• 公益社団法人日本薬学会の論文
• 1996-12-15

著者

• SAEKI Ken-ichi

  Faculty of Pharmaceutical Sciences, Nagoya City University

• KAWAZOE Yutaka

  Faculty of Pharmaceutical Sciences, Nagoya City University

• Saeki Ken-ichi

  エーザイ

• Saeki Ken-ichi

  Faculty Of Pharmaceutical Sciences Nagoya City University

• Saeki Ken-ichi

  エーザイ薬理安全性研究所

• Kawazoe Yutaka

  Faculty Of Pharmaceutical Science University Of Tokyo

• Kawazoe Y

  Nagoya City Univ. Nagoya Jpn

• Kawazoe Y

  Faculty Of Pharmaceutical Sciences Nagoya City University

• TOMOMITSU Masato

  Faculty of Pharmaceutical Sciences, Nagoya City University

• MOMOTA Kunitaka

  Morita Chemical Industries Co., Ltd.,

• KIMOTO Hiroshi

  National Industrial Research Institute of Nagoya

• Saeki Ken-ichi

  Faculty Of Engineering University Of Fukui

• Momota K

  Morita Chemical Ind. Co. Ltd. Osaka Jpn

• Momota Kunitaka

  Morita Chemical Industries Co. Ltd.

• Tomomitsu Masato

  Faculty Of Pharmaceutical Sciences Nagoya City University

関連論文

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• Clastogenicity of Quinoline and Monofluorinated Quinolines in Chinese Hamster Lung Cells
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• Activation of the Aryl Hydrocarbon Receptor by Methyl Yellow and Related Congeners : Structure-Activity Relationships in Halogenated Derivatives
• Fluorinated Benzo[h]quinolines and Benzo[f]quinolines
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• Clastogenicity of Quinoline Derivatives Tested by Micronucleus Induction in Vivo in the Hepatocytes of Partially Hepatectomized Mice
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